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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells

  • Heo, Kyun (Functional Genomics Branch, Division of Convergence Technology, National Cancer Center) ;
  • Park, Kyung-A (Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Kim, Yun-Hee (Molecular Imaging & Therapy Branch, Division of Convergence Technology, National Cancer Center) ;
  • Kim, Sun-Hee (Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Oh, Yong-Seok (Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Kim, In-Hoo (Molecular Imaging & Therapy Branch, Division of Convergence Technology, National Cancer Center) ;
  • Ryu, Sung-Ho (Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Suh, Pann-Ghill (Division of Molecular and Life Science, Pohang University of Science and Technology)
  • Published : 2009.10.31
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Abstract

Angiogenesis is essential for tumor growth and vascular endothelial cell growth factor (VEGF) plays a key role in this process. Conversely, sphingosine 1-phosphate (S1P) is a biologically active sphingolipid known to play a key role in cancer progression by regulating endothelial cell proliferation and migration. In this study, the authors found that S1P increases the level of VEGF mRNA in human umbilical vein endothelial cells (HUVECs) and immortalized HUVECs (iHUVECs). Additionally, S1P was found to increase VEGF promoter activity in MS-1 mouse pancreatic islet endothelial cells. Furthermore, a pharmacological inhibitory study revealed that $G_{\alpha i/o}$-mediated phospholipase C, Akt, Erk, and p38 MAPK signaling are involved in this S1P-induced expression of VEGF. A component of AP1 transcription factor is important for S1P-induced VEGF expression. Taken together, these findings suggest that S1P enhances endothelial cell proliferation and migrat ion by upregulating the expression of VEGF mRNA.

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References

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