The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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The Analgesic Effect of Different Dosing Methods When Using Transdermal Fentanyl Patches after Laparoscopic Cholecystectomy

복강경 담낭절제술에서 경피적펜타닐첩포의 투여방법에 따른 진통효과

  • Lee, Jae In (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Kim, Young Jae (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Cho, Kwang Rae (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Sang Eun (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Kim, Young Hwan (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Lim, Se Hoon (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Jeong Han (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Kun Moo (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Cheong, Soon Ho (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Choi, Young Kyun (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Shin, Chee Mahn (Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine)
  • 이재인 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 김영재 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 조광래 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 이상은 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 김영환 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 임세훈 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 이정한 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 이근무 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 정순호 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 최영균 (인제대학교 의과대학 부산백병원 마취통증의학교실) ;
  • 신치만 (인제대학교 의과대학 부산백병원 마취통증의학교실)
  • Received : 2009.05.29
  • Accepted : 2009.07.17
  • Published : 2009.08.01
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Abstract

Background: The advances in surgical technology, anesthesia and perioperative care have made it possible to perform laparoscopic cholecystectomy on an outpatient basis. This study was conducted to assess the analgesic effect and the adverse events of different dosing methods when using transdermal fentanyl patches (TDFPs) after laparoscopic cholecystectomy. Methods: Sixty patients who were to undergo laparoscopic cholecystectomy under general anesthesia were divided into two groups. Group 1: 2 TDFPs that released $12{\mu}g/h$ were applied after the induction of anesthesia and these 2 patches were removed after 24 hours. Group 2: 2 TDFPs that released $12{\mu}g/h$ were applied after the induction of anesthesia and one patch was removed after 7 hours and the other patch was removed after 24 hours. The intensity of the postoperative pain was assessed by using a visual analogue scale (VAS) and assessing the adverse events, including dizziness, pruritus and nausea/vomiting, were recorded for 48 hours postoperatively. Results: The VAS score of postoperative pain was not significantly different between the two groups at all times. The incidence of dizziness in groups I and II was 10 and 3, respectively, and the incidence of nausea/vomiting in group I and II was 4 and 0, respectively. The incidences of dizziness and nausea/vomiting in group II were significantly lower than those of group I (P<0.05). Conclusions: A dosing method that removes half of the TDFPs ($24{\mu}g/h$) after 7 hours of application caused a lower incidence of dizziness and nausea/vomiting without any significant difference of postoperative analgesic efficacy, as compared to leaving on both the TDFPs (24$\mu$g/h) for 24 hours after laparoscopic cholecystectomy.

Keywords

References

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