Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Effect of Alpinia officinarum on the Formation of Advanced Glycation Endproducts and Aldose Reductase Activity

  • Lim, Soon-Sung (Department of Food Science and Nutrition, Center for Efficacy Assessment and Development of Functional Foods and Drugs (RIC), Hallym University) ;
  • Kim, Hye-Mi (Department of Food Science and Nutrition, Center for Efficacy Assessment and Development of Functional Foods and Drugs (RIC), Hallym University) ;
  • Kim, Sun-Young (Department of Food Science and Nutrition, Center for Efficacy Assessment and Development of Functional Foods and Drugs (RIC), Hallym University) ;
  • Jeon, Young-Eun (Department of Food Science and Nutrition, Center for Efficacy Assessment and Development of Functional Foods and Drugs (RIC), Hallym University) ;
  • Lee, Yeon-Sil (Department of Food Science and Nutrition, Center for Efficacy Assessment and Development of Functional Foods and Drugs (RIC), Hallym University) ;
  • Kang, Il-Jun (Department of Food Science and Nutrition, Center for Efficacy Assessment and Development of Functional Foods and Drugs (RIC), Hallym University)
  • Published : 2009.02.28
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Abstract

The inhibition effects of an Alpinia officinarum (AO, Zingiberaceae) on the formation of advanced glycation end products, aldose reductase, and scavenging effect on 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical for the prevention and/or treatment of diabetic complications were investigated. The ethyl acetate fraction of AO was the most effective among all fractions. Through the tests with electron impact-mass spectrometry and nuclear magnetic resonance, two compounds (compound 1 and 2) finally obtained from the ethyl acetate fraction of AO were identified as galangin (1) and kaempferide (2), respectively. In addition, the compound 1 and 2 and the ethyl acetate fraction were compared for the prevention effect on advanced glycation end products, aldose reductase, and the scavenging effect on DPPH radical. The ethyl acetate fraction was significantly more effective than the 2 compounds for those preventive activities.

Keywords

References

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