Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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A Case Report of Huge Oral Verrucous Carcinoma in Oral Cavity

  • Kim, Jae-Jin (Dept. of Oral & Maxillofacial surgery, School of Medicine)
  • Published : 2009.02.28
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Abstract

Verrucous carcinoma is a distinctive form of low-grade squamous cell carcinoma. The tumor has an exophytic, cauliflower-like appearance, and usually occurs in males and tends to affect individuals over 60 years of age. It typically involves the oral cavity, larynx, esophagus and skin. Most intraoral cases involve the mandibular vestibule, the buccal mucosa and the hard palate. The cause is unknown, but most verrucous carcinomas arise from the oral mucosa in people who chronically use chewing tobacco or snuff. The treatment of oral verrucous carcinoma remains controversial. Whenever possible, surgically total excision and skin or mucosal grafting is recommended. After total excision of huge verrucous carcinoma,instead of dermal or mucosal grafting, we used artificial dermis silicone membrane. We had a good result without recurrence and present this case.

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References

  1. Ackerman LV: Verrucous carcinoma of the oral cavity. Surgery 1948;23:670-678
  2. Jordan RCK: Verrucous carcinoma of the mouth. J Can Dent Assoc 1995;61:797-801
  3. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology 2nd ed. Philadelphia, W.B. Saunders Co. 2002:304-306
  4. Garven TC, Thelmo WL, Victor J, Pertschuk L: Verrucous carcinoma of the leg positive for human papillomavirus DNA 11 and 18: a case report. Hum Pathol 1991;22:1170-1173 https://doi.org/10.1016/0046-8177(91)90272-Q
  5. Praetorius F: HPV-associated diseases of oral mucosa. Clin Dermatol 1997;15:399-413 https://doi.org/10.1016/S0738-081X(96)00157-5
  6. Miller CS, White DK: Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma: A retrospective review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:57-68 https://doi.org/10.1016/S1079-2104(96)80378-7
  7. Kamath VV, Varma RR, Gadewar DR, et al: Oral verrucous carcinoma: An analysis of 37 cases. J Craniomaxillofac Surg 1989;17:309-314 https://doi.org/10.1016/S1010-5182(89)80059-9
  8. Link JO, Kaugars GE, Burns JC: Comparison of the oral carcinomas in smokeless tobacco users and nonusers. J Oral Maxillofac Surg 1992;50:452-455 https://doi.org/10.1016/S0278-2391(10)80315-5
  9. Miller CS, Johnstone BM: Human papillomavirus as a risk factor for oral squamous cell carcinoma: A meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:622- 635 https://doi.org/10.1067/moe.2001.115392
  10. Batsakis JG, Hybels R, Crissman JD, Rice DH: The pathology of head and neck tumors: verrucous carcinoma. Part 15. Head Neck Surg 1982;5:29-38 https://doi.org/10.1002/hed.2890050107
  11. Tharp II ME, Shidnia H: Radiotherapy in the treatment of verrucous carcinoma of the head and neck. Laryngoscope 1995;105:391-396 https://doi.org/10.1288/00005537-199504000-00011
  12. Kapstad B, Bang G: Verrucous carcinoma of the oral cavity treated with Bleomycin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1976;42:925-944 https://doi.org/10.1016/0030-4220(76)90209-7
  13. Clairmont AA, Conley JJ: Primary carcinoma of the mastoid bone. Ann Otol Rhinol Laryngol 1997;86:306-309
  14. Koch BB, Trask DK, Hoffman HT, Karnell LH, Robinson RA, Zen W: National survey of head and neck verrucous carcinoma: pattern of presentation, care, and outcome. Cance 2001;92:110-120 https://doi.org/10.1002/1097-0142(20010701)92:1<110::AID-CNCR1298>3.0.CO;2-K
  15. Shin DM, Lee JS, Lippman SM, Lee JJ, Tu ZN, Choi G, et al:p53 Expression: predicting recurrence and second primary tumors in head and neck squamous cell carcinoma. JNCI 1996;88:519-529 https://doi.org/10.1093/jnci/88.8.519
  16. Vidyasagar MS, Fernandes DJ, Pai Kasturi D, Akhileshwaran R, Rao K, Rao s, et al: Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases. Acta Oncol 1992;31:43-47 https://doi.org/10.3109/02841869209088264
  17. McClure DL, Gullane PJ, Slinger RP, et al: Verrucous carcinoma- changing concepts in management. J Otolaryngol 1984;13:7-12