Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

The Effect of Pharmacopuncture of Mori Cortex on Galactosamine-induced Liver Injury in Rats

간유(肝兪)($BL_{18}$) 상백피(桑白皮)약침이 Galactosamine에 의해 유발된 흰쥐의 간(肝)손상에 미치는 영향

  • Wi, Jun (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Kim, Jae-Hong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Yoon, Yeo-Choong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Wei, Tung-Shuen (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Yoon, Dae-Hwan (Dept. of Meridians & Acupoints, College of Oriental Medicine, Dongshin University)
  • 위준 (동신대학교 한의과대학 침구학교실) ;
  • 김재홍 (동신대학교 한의과대학 침구학교실) ;
  • 윤여충 (동신대학교 한의과대학 침구학교실) ;
  • 위통순 (동신대학교 한의과대학 침구학교실) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실)
  • Published : 2009.10.20
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Abstract

Objectives : This study was designed to investigate the effect of pharmacopuncture of Mori Cortex on galactosamine-induced liver injury in rats. Methods : Male Sprague-Dawley rats were divided into 5 groups; Normal, liver injury not induced and not treated group. Control, the liver injury-induced and not treated group. Saline group, the liver injury-induced and saline injection at $BL_{18}$. HA-1 and HA-2 group, the liver injury-induced and pharmacopuncture of Mori Cortex applied to $BL_{18}$, each $1.3{\mu}g/g$, $2.6{\mu}g/g$. Then we observed the changes of ${\gamma}$-GTP, GOT, GPT, LDH, total cholesterol, triglyceride, total bilirubin. Results : Pharmacopuncture of Mori Cortex treatment significantly inhibited the activities of ${\gamma}$-GTP, GOT, total cholesterol, triglyceride and total bilirubin in HA-1 group. ${\gamma}$-GTP, GTP, LDH, ${\gamma}$-GTP levels were significantly inhibited in HA-2 group. Conclusions : These results demonstrate that the reduce of hepatic enzyme activation and lipid accumulation by pharmacopuncture of Mori Cortex may be by an antioxidant properties of Mori Cortex.

Keywords

References

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