Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Yijin-tang-gamibang Extracts on Reflux Esophagitis

역류성 식도염에 대한 이진탕가미방(二陣湯加味方) 효과 연구

  • Hwang, Gee-Young (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Dae-Jun (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Byun, Joon-Seok (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
  • 황지영 (대구한의대 한의과대학 비계내과학교실) ;
  • 김대준 (대구한의대 한의과대학 비계내과학교실) ;
  • 변준석 (대구한의대 한의과대학 비계내과학교실)
  • Published : 2009.10.25
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Abstract

The object of this study was to observe the protective effects of Yijin-tang-gamibang (YJGMB), Yijin-tang has been traditionally used as Korean medicine for treating various digestive diseases. The study showed that it is effective on reflux esophagitis induced by pylorus and forestomach ligation in rats. Three different dosages of Yijin-tang-gamibang extracts, 300, 150 and 75 mg/kg, were once orally administered 1 hour before pylorus ligation. 6 groups, each of 8 rats per group were used in the present study. The results were compared with Omeprazole, antioxidant and proton pump inhibitor, 30 mg/kg treated group. Yijin-tang-gamibang extracts 300 mg/kg were showed similar or slightly lower effects as compared with 30 mg/kg of omeprazole in the present study. Detail mechanism studies should be conduced in future with the efficacy tests of individual herbal composition of Yijin-tang-gamibang and the screening of the biological active compounds in herbs.

Keywords

References

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