Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Magnolia Obovata Water-extracts on the Atherosclerosis Treated with High-cholesterol Diet in Rat

고(高)콜레스테롤 식이로 유발된 흰쥐 동맥경화에 Magnolia obovata가 미치는 영향

  • Na, Sun-Taek (Cardiovascular Medical Research Center and Department of Diagnostics, College of Korean Medicine, Dongguk University) ;
  • Lee, Young-Yang (Cardiovascular Medical Research Center and Department of Diagnostics, College of Korean Medicine, Dongguk University) ;
  • Kim, Young-Hwan (Cardiovascular Medical Research Center and Department of Diagnostics, College of Korean Medicine, Dongguk University) ;
  • Yang, Young-Yi (Cardiovascular Medical Research Center and Department of Diagnostics, College of Korean Medicine, Dongguk University) ;
  • Jung, Hyun-Jung (Cardiovascular Medical Research Center and Department of Diagnostics, College of Korean Medicine, Dongguk University) ;
  • Kim, Jae-Eun (Cardiovascular Medical Research Center and Department of Diagnostics, College of Korean Medicine, Dongguk University) ;
  • Park, Won-Hwan (Cardiovascular Medical Research Center and Department of Diagnostics, College of Korean Medicine, Dongguk University)
  • 나선택 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 이용양 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 김영환 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 양영이 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 정현정 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 김재은 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실) ;
  • 박원환 (동국대학교 한의과대학 기초의과학연구센터 & 진단학교실)
  • Published : 2009.10.25
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Abstract

Magnolia obovata exhibit several beneficial effects including anti-oxidant effects. Magnolia obovata is used as a therapeutic agent to stop hemorrhages and a tonic to promoted health in Korean and Chinese medicine. The pharmacokinetic profiles of the main Magnolia obovata is still not accurately investigated. In present study, I examined the effects of water extracts of Magnolia obovata on atherosclerosis induced high cholesterol diet in rats in serum and abdominal aorta. A total of 3-week old 9 male rats of Sprague-Dawley were divided into 3 groups and fed with the basal diet (normal group), high cholesterol diet (atherosclerosis induced group) for 8 weeks, high cholesterol diet supplemented with water extracts of Magnolia obovata (Magnolia obovata group) for 2 weeks. And rats were sacrificed, serum lipid level, abodominal aortic anti-oxidant activities and lipid peroxide were measured. These results indicated that serum total cholesterol, LDL-cholesterol, triglycerides concentration significantly lower in Magnolia obovata group than high cholesterol diet group. But HDL-cholesterol concentration had significantly higher in Magnolia obovata group than high cholesterol diet group. In conclusion, Magnolia obovata controls of lipid level of hyperlipidemia and hypercholesterolemia, thus suppresses the proliferation of intima in endothelial cells, which is risk factors of atherosclerosis induced high cholesterol diet in rats. I consider as Magnolia obovata is worth to using as atherosclerosis treatment.

Keywords

References

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