Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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A Case of Acute Renal Failure due to Rhabdomyolysis Associated with Neuroleptic Malignant Syndrome

항정신병약물악성증후군에 동반한 횡문근융해증으로 인한 급성 신부전 1례

  • Park, Kyu-Hee (Department of Pediatrics, College of Medicine, Korea University) ;
  • Jung, Seong-Kwan (Department of Pediatrics, College of Medicine, Korea University) ;
  • Yim, Hyung-Eun (Department of Pediatrics, College of Medicine, Korea University) ;
  • Yoo, Kee-Hwan (Department of Pediatrics, College of Medicine, Korea University) ;
  • Hong, Young-Sook (Department of Pediatrics, College of Medicine, Korea University) ;
  • Lee, Joo-Won (Department of Pediatrics, College of Medicine, Korea University)
  • 박규희 (고려대학교 의과대학 소아과학교실) ;
  • 정성관 (고려대학교 의과대학 소아과학교실) ;
  • 임형은 (고려대학교 의과대학 소아과학교실) ;
  • 유기환 (고려대학교 의과대학 소아과학교실) ;
  • 홍영숙 (고려대학교 의과대학 소아과학교실) ;
  • 이주원 (고려대학교 의과대학 소아과학교실)
  • Published : 2009.10.31
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Abstract

Neuroleptic malignant syndrome (NMS) is a rare, but a potentially life threatening condition associated with the use of antipsychotics. The most frequent signs and symptoms of NMS include fever, muscle rigidity, autonomic dysfunction such as tachycardia, tachypnea, and labile blood pressure. Acute complications of NMS include disseminated intravascular coagulation, sepsis, seizure, myocardial infarction, acute renal failure due to rhabdomyolysis and death. We report a rare case of acute renal failure due to rhabdomyolysis associated with neuroleptic malignant syndrome.

항정신병약물악성증후군은 항정신병약물의 사용과 관련하여 드물게 발생하는 부작용으로 생명을 위협하는 질환으로 의식변화, 고열증, 근육강직의 특징적 증상을 보인다. 항정신병약물악성증후군 환자에서 고열증과 근육강직으로 인하여 횡문근융해증이 발생하여 합병증으로 급성 신부전이 생기는 경우가 드물게 발생하며 심한 경우 투석 등의 치료가 필요하며 생명에 위협이 되므로 빠른 진단과 치료가 요구된다. 저자들은 소아에서 보고되지 않던 항정신병약물악성증후군에 동반하여 횡문근융해증을 보인 급성 신부전의 예를 경험하였기에 보고하는 바이다.

Keywords

References

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