Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Biological Activities of Seven Melania Snails in Korea

국내산 7종 다슬기 추출물의 생리활성 특성 비교

  • Kim, Yeon-Kye (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Moon, Ho-Sung (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Lee, Moon-Hee (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Park, Mi-Ju (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Lim, Chi-Won (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Park, Hee-Yeon (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Park, Jin-Il (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Yoon, Ho-Dong (Food and Safety Research Center, National Fisheries Research and Development Institute) ;
  • Kim, Dae-Hee (Inland Aquaculture Research Institute, National Fisheries Research and Development Institute)
  • 김연계 (국립수산과학원 식품안전연구단) ;
  • 문호성 (국립수산과학원 식품안전연구단) ;
  • 이문희 (국립수산과학원 식품안전연구단) ;
  • 박미주 (국립수산과학원 식품안전연구단) ;
  • 임치원 (국립수산과학원 식품안전연구단) ;
  • 박희연 (국립수산과학원 식품안전연구단) ;
  • 박진일 (국립수산과학원 식품안전연구단) ;
  • 윤호동 (국립수산과학원 식품안전연구단) ;
  • 김대희 (국립수산과학원 내수면양식연구소)
  • Published : 2009.10.31
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Abstract

This study was conducted to compare the biological activities of 7 melania snails from the family Pleuroceridae (Semisulcospira coreana, Koreanomelania nodifila, Semisulcospira forticosta, Koreoleptoxis globus ovalis, Semisulcospira libertina, Semisulcospira tegulata and Semisulcospira gottschei) in Korea. Among the 7 species, S. coreana, Korean. nodifila, S. forticosta and S. gottschei showed over 80% cytotoxicities on three cancer cell lines (SNU-1, A549 and Hep 3B) compared to the non-treatment, whereas S. libertina and S. tegulata showed almost no growth inhibition activities on the same cancer cell lines. In relation to ACE inhibition activity, only S. coreana, Korean. nodifila, and S. forticosta showed over 60% ACE inhibition activities, whereas other melania snails exhibited inhibition activities of lower than 25%. DPPH radical scavenging activities were also determined, and used to categories melania snails into three groups based on Duncan's multiple range test at P<0.05. The amount of TNF-${\alpha}$ produced by in vitro mouse peritoneal macrophage was determined according to bioactivity on L-929 cells. Three melania snails, S. coreana, Korean. nodifila and S. gottschei, exhibited 95.2%, 89.7% and 93.7% cell death(%) on L-929 cells, respectively. Glucose-6-phosphate dehydrogenase inhibitory activity was also obtained in the extract of S. coreana (31.9%) and Korean. nodifila (28.1%), showing that these extracts can be used as supplemental dietary health foods. In conclusion, we believe that the extracts of melania snails should be given due consideration in functional health food development.

Keywords

References

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