Parasites, Hosts and Diseases

  • 제47권4호
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  • Pages.421-424
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  • 2009
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  • 2982-5164(pISSN)
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  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
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Glutathione Reductase and Thioredoxin Reductase: Novel Antioxidant Enzymes from Plasmodium berghei

  • Kapoor, Gaurav (Laboratory of Parasitology and Immunology, Department of Bioseienees, Himachal Pradesh University) ;
  • Banyal, Harjeet Singh (Laboratory of Parasitology and Immunology, Department of Bioseienees, Himachal Pradesh University)
  • 발행 : 2009.12.31
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초록

Malaria parasites adapt to the oxidative stress during their erythrocytic stages with the help of vital thioredoxin redox system and glutathione redox system. Glutathione reductase and thioredoxin reductase are important enzymes of these redox systems that help parasites to maintain an adequate intracellular redox environment. In the present study, activities of glutathione reductase and thioredoxin reductase were investigated in normal and Plasmodium berghei-infected mice red blood cells and their fractions. Activities of glutathione reductase and thioredoxin reductase in P. berghei-infected host erythrocytes were found to be higher than those in normal host cells. These enzymes were mainly confined to the cytosolic part of cell-free P. berghei. Full characterization and understanding of these enzymes may promise advances in chemotherapy of malaria.

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피인용 문헌

  1. Cysteine-3 and cysteine-4 are essential for the thioredoxin-like oxidoreductase and antioxidant activities of Plasmodium falciparum macrophage migration inhibitory factor vol.50, pp.11, 2011, https://doi.org/10.1016/j.freeradbiomed.2011.03.012
  2. Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice vol.12, pp.None, 2013, https://doi.org/10.1186/1475-2875-12-315
  3. Differential Effect of Antioxidants Glutathione and Vitamin C on the Hepatic Injuries Induced by Plasmodium berghei ANKA Infection vol.2021, pp.None, 2021, https://doi.org/10.1155/2021/9694508