Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Cytologic Aspect of Fibrous Osteodystrophy in a Juvenile Siberian Husky

어린 Siberian Husky 견의 섬유성 골형성장애의 세포학적 고찰 증례

  • Jee, Hyang (Department of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Choi, Ul-Soo (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Chonbuk National University) ;
  • Latouche, Jean-Sebastien (Veterinary Cytopathology, Inc. VDIC) ;
  • Bang, Dong-Ha (Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Dae-Yong (Department of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Cheol-Yong (Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Youn, Hwa-Young (Internal Medicine, College of Veterinary Medicine, Seoul National University)
  • 지향 (서울대학교 수의과대학 수의병리학과) ;
  • 최을수 (전북대학교 수의과대학 수의임상병리학과) ;
  • ;
  • 방동하 (서울대학교 수의과대학 수의내과학) ;
  • 김대용 (서울대학교 수의과대학 수의병리학과) ;
  • 황철용 (서울대학교 수의과대학 수의내과학) ;
  • 윤화영 (서울대학교 수의과대학 수의내과학)
  • Published : 2009.02.27
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Abstract

A 5-month-old intact female Siberian Husky dog was presented for evaluation of severely enlarged maxilla. Abnormalities in CBC, serum chemistry and urinalysis indicated purulent inflammation and renal failure. Cytologic examination of the swollen maxilla showed a mixed population of multinucleated giant cells and round to polygonal to spindle shaped cells either individualized or aggregated. Both type of cells showed moderate anisokaryosis, and anisocytosis, prominent nucleolus or multiple nucleoli, and coarse chromatin. On histopathology maxilla and turbinate were diffusely expanded and replaced by variably dense fibrous connective tissue, and the kidneys showed changes consistent with renal dysplasia. Based on these findings, the diagnosis of fibrous osteodystrophy due to renal dysplasia and fibrosis was made. Despite the supportive care, the dog continued to decline and was euthanized.

5개월령의 거세하지 않은 암컷 시베리안 허스키가 상악 병변의 평가를 위해 내원하였다. CBC, 혈청 화학, 요검사 소견에서 염증과 신부전이 지시되었다. 병변의 세포학 검사에서는 거대 다핵 세포들과 원형$\sim$방추형의 다향한 모양의 세포들이 개별적으로 탈락되거나 군집을 형성하였다. 두 종류의 세포들 모두 중등도의 핵 대소부동증과 세포부동증을 보였고, 뚜렷한 한 개의 핵소체 또는 여러 개의 작은 핵소체를 갖고 있었으며 성긴 염색질이었다. 조직병리학적 검사 결과, 상악과 비갑개는 전반적으로 확장되어 있었으며 결합조직에 의해 대체되어 있었으며 신장에서는 형성 이상이 관찰되었다. 이러한 결과를 바탕으로, 신장형성이상과 섬유화로 인한 섬유성 골형성장애로 진단되었다. 대증적인 처치에도 불구하고 환자의 상태는 악화되어 안락사 되었다.

Keywords

References

  1. Burk RL, Barton CL. Renal failure and hyperparathyroidism in an Alaskan Malamute pup. J Am Vet Med Assoc 1978; 172: 69-72
  2. Carmichael DT, Williams CA, Aller MS, Renal dysplasia with secondary hyperparathyroidism and loose teeth in a young dog, J Vet Den 1995; 12: 143-146
  3. Gupta K, Dey P, Goldsmith R, Vasishta RK. Cytologic features of central giant-cell granuloma of the jaw. Diagn Cytopathol 2004; 31: 113-115 https://doi.org/10.1002/dc.20078
  4. Haziroglu R, Kul O, Unca R, Guvenc T. Osteoclast-like giant cell tumour arising from the kidney in a dog. Acta Veterinaria Hungarica 2005; 53: 225-230 https://doi.org/10.1556/AVet.53.2005.2.7
  5. Kaufman CF, Soirez RF, Tasker JP. Renal Cortical hypoplasia with secondary hyperparathyroidism in the dog. J Am Vet Med Assoc 1969; 155: 1679-1685
  6. Nergin A, Bernardini M, Diana A, Castagnaro M. Giant cell osterosarcoma in the calvarium of a cat. Vet Pathol 2006; 43: 179-182 https://doi.org/10.1354/vp.43-2-179
  7. McManus PM, Wood AK, Christiansen JS, Craig LE. Lytic lesion in the distal humerus of a dog. Vet Clin Pathol 2001; 30: 121-123 https://doi.org/10.1111/j.1939-165X.2001.tb00419.x
  8. Newman SJ, Confer AW, Panciera RJ. Urinary System. In: McGavin MD, Zachary JF. Eds. Pathologic basis of veterinary disease, 4th ed. St Louis: Mosby Elsevier. 2007: 670- 672
  9. Nielsen SW, McSherry BJ. Renal hyperparathyroidism (rubber jaw. syndrome) in a dog. J Am Vet Med Assoc 1954; 124: 270-274
  10. Ozcan C, Apaydin FD, Gorur K, Apa DD. Peripheral giant cell granuloma of the mandibular condyle presenting as a preauricular mass. Eur Arch torhinolaryngol 2005; 262: 178-181 https://doi.org/10.1007/s00405-004-0758-4
  11. Perez-Guillermo M, Acosta-Ortega J, Garcia-Solano J, Ramos-Freixa J. Cytologic aspect of brown tumor of hyperparathyroidism. Report of a case affecting the hard palate. Diagn Cytopathol 2006; 34: 291-294 https://doi.org/10.1002/dc.20434
  12. Smart ME, Fletch SM. Progressive renal failure in a dog. J Am Vet Med Assoc 1972; 161: 1402-1410
  13. T Trigo FJ, Leathers CW, Brobst DF. A Comparison of canine giant cell tumor and giant cell reparative granuloma of bone. Vet Pathol 1983; 20: 215-222
  14. Vilafranca M, Ferrer L. Juvenile nephropathy in Alaskan Malamute littermates. Vet Pathol 1994; 31: 375-377 https://doi.org/10.1177/030098589403100311
  15. Waters CB, Morrison WB, DeNicolar DB, Widmer WR, White MR. Giant cell variant of malignant fibrous histiocytoma in dogs: 10 cases (1986-1993). J Am Vet Med Assoc 1994; 205: 1420-1424
  16. Weisbrode SE. Bone and Joints. In: McGavin MD, Zachary JF. Eds. Pathologic basis of veterinary disease. 4th ed. St Louis: Mosby Elsevier. 2007: 1071-1077
  17. Yamamoto T, Nagira K, Akisue T, Marui T, Hitora T, Kawamoto T, Yoshiya S, Kurosaka M, Tsukamoto R. Fineneedle aspiration biopsy of solid aneurysmal bone cyst in the humerus. Diagn Cytopathol 2003; 28; 159-162 https://doi.org/10.1002/dc.10248