Neonatal Medicine

  • 제16권1호
  • /
  • Pages.1-9
  • /
  • 2009
  • /
  • 2287-9412(pISSN)
  • /
  • 2287-9803(eISSN)
대한신생아학회 (The Korean Society of Neonatology)
권호 표지

신생아 발작의 발견 및 진단

Detection and Diagnosis of Neonatal Seizures

  • 은백린 (고려대학교 의과대학 소아과학교실)
  • Eun, Baik-Lin (Department of Pediatrics, Korea University College of Medicine)
  • 발행 : 2009.05.31

⟨ 이전 논문 다음 논문 ⟩

초록

Seizures are the most common clinical manifestation of a neurologic insult during the neonatal period. Neonatal seizures continue to present a diagnostic and therapeutic challenge to pediatricians because the recognition and classification of neonatal seizures remains problematic, particularly when clinicians rely only on clinical criteria. Neonatal seizures can permanently disrupt neuronal development, induce synaptic reorganization, alter plasticity, and "prime" the brain to increased damage from seizures later in life. Since neonatal seizures, particularly status epilepticus, predict an increased risk for later epilepsy and other neurologic sequelae, accurate diagnoses are needed for aggressive antiepileptic drug use. The present review summarizes the pathophysiology, etiology, and diagnosis of neonatal seizures.

키워드

참고문헌

  1. Volpe JJ. Neonatal seizures. In : Neurology of the newborn, 4th ed. Philadelphia: WB Sanders Co, 2001:178-214
  2. Lanska MJ, Lanska DJ. Neonatal seizures in the United States: results of the Natinal Hospital Discharge Survey, 1980-1991. Neuroepidemiology 1996; 15:117-25. https://doi.org/10.1159/000109898
  3. Lanska MJ, Lanska DJ, Baumann RJ, Kryscio RJ. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology 1995;45:724- 32. https://doi.org/10.1212/WNL.45.4.724
  4. Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr 1999;134:71-5. https://doi.org/10.1016/S0022-3476(99)70374-4
  5. Saliba RM, Annegers JF, Waller DK, Tyson JE, Mizrahi EM. Incidence of neonatal seizures in Harris County, Texas, 1992-1994. Am J Epidemiol 1999;150:763-9. https://doi.org/10.1093/oxfordjournals.aje.a010079
  6. Eriksson M, Zetterstrom R. Neonatal convulsions. Incidence and causes in the Stockholm area. Acta Paediatr Scand 1979;68:807-11. https://doi.org/10.1111/j.1651-2227.1979.tb08216.x
  7. Wyllie E, Gupta A, Lachhwani DK. The treatment of epilepsy - principles & practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2006:488.
  8. Silverstein FS, Jensen FE. Neonatal seizures. Ann Neurol 2007;62:112-20. https://doi.org/10.1002/ana.21167
  9. Zupanc ML. Neonatal seizures. Pediatr Clin North Am 2004;51:961-78. https://doi.org/10.1016/j.pcl.2004.03.002
  10. Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke T A, et al. NKCC1 transporter facilitates seizures in the developing brain. Nat Med 2005;11:1205-13. https://doi.org/10.1038/nm1301
  11. Scher MS. Neonatal seizures and brain damage. Neurol 2003;29:381-90.
  12. Pisani F, Cerminara C, Fusco C, Sisti L. Neonatal status epilepticus vs recurrent neonatal seizures. Neurology 2007;69:2177-85. https://doi.org/10.1212/01.wnl.0000295674.34193.9e
  13. Granelli SLP, McGrath JM. Neonatal seizures: diagnosis, pharmacologic interventions, and outcomes. J Perinat Neonatal Nurs 2004;18:275-87. https://doi.org/10.1097/00005237-200407000-00009
  14. Scher MS, Painter MJ. Controversies concerning neonatal seizures. Pediatr Clin North Am 1989;36: 281-310. https://doi.org/10.1016/S0031-3955(16)36650-0
  15. Painter MJ, Bergman L, Crumrine P. Neonatal seizures. Pediatr Clin North Am 1986;33:91-109. https://doi.org/10.1016/S0031-3955(16)34971-9
  16. Scher MS. Seizures in the newborn infant. Diagnosis, treatment and outcome. Clin Perinatol 1997;24: 735-72.
  17. Tharp BR. Neonatal seizures and syndromes. Epilepsia 2002;43:2-10.
  18. Clancy RR. Prolonged electroencephalogram monitoring for seizures and their treatment. Clin Perinatol 2006;33:649-65. https://doi.org/10.1016/j.clp.2006.06.004
  19. Rennie JM, Boylan GB. Neonatal seizures and their treatment. Curr Opin Neurol 2003;16:177-81. https://doi.org/10.1097/00019052-200304000-00010