Annals of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지)

The Korean Association of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회)
권호 표지

A Case of Adrenocortical Oncocytoma Misrecognized for Fibrolamellar Hepatocellular Carcinoma

섬유총판 간세포암으로 오인된 부신 피질 호산성 과립세포종 1예

  • Park, In-Soo (Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Choi, Seung-Bong (Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Cho, Byung-Hoon (Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Nam, Woo-Suk (Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Won, Yong-Sung (Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea)
  • 박인수 (가톨릭대학교 의과대학 성빈센트병원 외과학교실) ;
  • 최승봉 (가톨릭대학교 의과대학 성빈센트병원 외과학교실) ;
  • 조병훈 (가톨릭대학교 의과대학 성빈센트병원 외과학교실) ;
  • 남우석 (가톨릭대학교 의과대학 성빈센트병원 외과학교실) ;
  • 원용성 (가톨릭대학교 의과대학 성빈센트병원 외과학교실)
  • Published : 2009.09.30

⟨ Previous Next ⟩

Abstract

Adrenocortical oncocytoma is a very rare disease which has been reported in 40 cases. A 27- years-old female patient was admitted for a suspicious hepatocellular mass on ultrasonogram On CT scan, sono-guided needle biopsy and 18F-FDG PET scan, all results were unsatisfactory. During laparotomy, the mass was originated from Rt. adrenal gland and liver was pushed sideward by the mass. On pathology report, an adrenocortical oncocytoma was diagnosed. Adrenocortical oncocytoma has pathological characteristics comprised of oncocytes with granular, eosinophilic cytoplasm, and sufficient mitochondria in their cytoplasm. There were no established criteria for differential diagnose between benign and malignant adrenocortical oncocytoma. There are no sufficient data for the long-term outcome of adrenocortical oncocytoma in the medical literature. Thus we report a case of adrenocortical oncocytoma with review of the related literature.

Keywords

References

  1. Hamperl H. Oncocytes and tumors of the salivary glands. Virchows Arch A 1931;282:724-736. https://doi.org/10.1007/BF01887014
  2. Hamperl H. Benign and malignant on cocytoma. Cancer 1962;I5:1019-1027.
  3. Bengoechea O, Sanchez F, Larrinaga B, Martinez- Penuela JM. Oncocytic adenocarcinoma arising in Warthin's tumor. Pathol Res Pract 1989;185(6):907-911;discussion 911-914 https://doi.org/10.1016/S0344-0338(89)80296-1
  4. Corsi A, Riminucci M, Petrozza V et al. Incidentally detected giant on cocytoma arising in retroperitoneal heterotopic adrenal tissue. Arch Pathol Lab Med. 2002;126(9):1118-1122.
  5. Kakimoto S, Yushita Y, Sanefuji T. Non-hormonal adrenocortical adenoma with oncocytoma-like appearance. Hinyokika Kiyo 1986;32(5):757-763.
  6. Sasano H, Suzuki T, Sano T, Kameya T, Sasano N, Nagura H. Adrenocortical oncocytoma. A true non-functioning adrenocortical tumor. Am J Surg Pathol 1991t;15(10):949-956 https://doi.org/10.1097/00000478-199110000-00005
  7. Kurek R, Von Knobloch R, Feek U, Heidenreich A, Hofmann R. Local recurrence of an oncocytic adrenocortical carcinoma with ovary metastasis. J Urol 2001;166(3):985. https://doi.org/10.1016/S0022-5347(05)65882-X
  8. Bisceglia M, Ludovico O, Di Mattia A et al. Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol 2004 Jul;12(3):231-243. https://doi.org/10.1177/106689690401200304
  9. Weiss LM. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 1984 Mar;8(3) :163-169. https://doi.org/10.1097/00000478-198403000-00001
  10. Medeiros LJ, Weiss LM. New developments in the pathologic diagnosis of adrenal cortical neoplasms. A review. Am J Clin Pathol 1992;97(1):73-83. https://doi.org/10.1093/ajcp/97.1.73
  11. Lin BT, Bonsib SM, Mierau GW, Weiss LM, Medeiros LJ. Oncocytic adrenocortical neoplasms: a report of seven cases and review of the literature. Am J Surg Pathol 1998;22(5):603-614. https://doi.org/10.1097/00000478-199805000-00012
  12. Wu SL, Biddle DA, Ordonez NG, Krishnamurthy S, Ayala AG, Ro JY. Oncocytic adrenocortical neoplasm: A clinicopathologic and immunohistochemical study of seven cases. Mod Pathol 2002;15:121.
  13. Aubert S, Wacrenier A, Leroy X et al. Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors. Am J Surg PathoI 2002;26(12):1612-1619. https://doi.org/10.1097/00000478-200212000-00009
  14. Vargas MP, Vargas HI, Kleiner DE, Merino MJ. The role of prognostic markers (MiB-1, RB, and bcl-2) in the diagnosis of parathyroid tumors. Mod Pathol 1997;10(1):12-17.
  15. Kitching PA, Patel V, Harach HR. Adrenocortical oncocytoma. J Clin Pathol 1999;52(2):151-153. https://doi.org/10.1136/jcp.52.2.151
  16. Luton JP, Cerdas S, Billaud L et al. Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. N Engl J Med 1990;322(17):1195-1201. https://doi.org/10.1056/NEJM199004263221705
  17. McLoughlin RF, Bilbey JH. Tumors of the adrenal gland: findings on CT and MR imaging. AJR Am J Roentgenol 1994;163(6):1413-1418. https://doi.org/10.2214/ajr.163.6.7992738
  18. Acar C, Akkas BE, Sen I, Sozen S, Kitapci MT. False positive 18F-FDG PET scan in adrenal oncocytoma. Urol Int 2008;80(4):444-447. https://doi.org/10.1159/000132706
  19. Sarode VR, Castellani R, Post A. Fine-needle aspiration cytology and differential diagnoses of fibrolamellar hepatocellular carcinoma metastatic to the mediastinum: case report. Diagn Cytopathol 2002;26(2):95-98. https://doi.org/10.1002/dc.10047
  20. Guillermo MP, Masgrau NA, Garcia- Solano J, Sola- Perez J, Agustin PA. Cytologic aspect of fibrolamellar hepatocellular carcinoma in fine needle aspirates. Diagn Cytopathol 1999;21:180-187. https://doi.org/10.1002/(SICI)1097-0339(199909)21:3<180::AID-DC7>3.0.CO;2-O