Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Soluble Collagen Peptides Extract Derived from Mugil cephalus Scale on the Blood Glucose and Lipid Metabolism in Diabetic Rats

숭어(Mugil cephalus) 비늘 유래 가용성 콜라겐 펩타이드가 당뇨성 흰쥐의 혈당 및 지질대사에 미치는 영향

  • Kim, Han-Soo (Dept. of Food Science & Technology, Pusan National University) ;
  • Yoon, Ho-Dong (Food & Safety Research Center, National Fisheries Research & Development Institute) ;
  • Seong, Jong-Hwan (Dept. of Food Science & Technology, Pusan National University) ;
  • Lee, Young-Guen (Dept. of Food Science & Technology, Pusan National University) ;
  • Xie, Cheng-Liang (Dept. of Food Science & Technology, Pusan National University) ;
  • Kim, Su-Ha (Dept. of Food Science & Technology, Pusan National University) ;
  • Choi, Woo-Seok (Dept. of Food Science & Technology, Pusan National University)
  • 김한수 (부산대학교 식품공학과) ;
  • 윤호동 (국립수산과학원 식품안전연구단) ;
  • 성종환 (부산대학교 식품공학과) ;
  • 이영근 (부산대학교 식품공학과) ;
  • ;
  • 김수하 (부산대학교 식품공학과) ;
  • 최우석 (부산대학교 식품공학과)
  • Published : 2009.12.30
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Abstract

This study was conducted to examine the effects of soluble collagen peptides extract supplementation on the improvement of blood glucose, lipid components and enzyme activities in the sera of streptozotocin (STZ, 55 mg/kg BW, IP injection)-induced diabetic rats fed on experimental diets for 5 weeks. The concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, triglycerides (TG) and phospholipids (PL) in serum were remarkably higher in the diabetic group (group SW) and STZ (IP)+collagen peptides extract supplementation group (group SFW) than those in the control group (group CG, basal diet + water). However the concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, TG and PL in serum were lower in the SFW group than in the SW group, whereas the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration in the SFW group were higher than in the SW group. The activities of alkaline phosphatase (ALP) and aminotransferase (AST, ALT) in serum were lower in the SFW group than in the diabetic SW group. The results shown above suggest that soluble collagen peptides extract supplementation effectively improves blood glucose, lipid compositions and enzyme activities in the sera of STZ induced diabetic rats.

숭어(Mugil cephalus) 비늘에서 추출한 가용성 펩타이드 추출물이 streptozotocin (STZ 55 mg/kg BW, IP injection)으로 유도된 당뇨성 Sprague Dawley계 수컷 흰쥐의 있어서, 혈당 및 혈청 지질개선효과와 당질대사 이상 등에 관여하는 효소의 활성 변동을 생리생화학적 측면에서 검토하기 위하여 본 실험을 수행하였다. 대조군인 CG군을 비롯한 STZ 당뇨 유발군(SW군), 당뇨 유발에 콜라겐 펩타이드를 섭취시킨 군(SFW군)을 5주간 실험 사육한 결과, 혈당 농도는 당뇨 유발군에 콜라겐 펩타이드를 급여함으로서 유의적인 감소 효과를 보였다. 또한 혈청 총 콜레스테롤, 동맥경화지수, LDL, LDL-콜레스테롤, 중성지방 및 인지질 농도, 유리 콜레스테롤, 콜레스테롤 에스테르 비 등은 콜라겐 펩타이드를 섭취시킨 군(SFW군)에서 농도가 저하되는 것으로 나타났다. 한편, HDL-콜레스테롤 및 총 콜레스테롤에 대한 HDL-콜레스테롤 비 등은 콜라겐펩타이드 섭취(SFW군)에 의해서 증가되는 것으로 나타났다. 혈청 중 alkaline phosphatase (ALP) 및 aminotransferase(AST, ALT)의 활성은 STZ으로 당뇨를 유도 시킨 후 콜라겐펩타이드를 섭취시킴으로서 저하되는 것으로 나타났다. 따라서 본 실험 결과 등에서 콜라겐 펩타이드 추출물이 STZ으로 유발된 당뇨성 흰쥐의 혈당조절 기능 및 지질대사 이상 등에서 오는 당뇨성 질환의 예방 및 개선에 효과가 있을 것으로 사료된다.

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