Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Harmful Effects of Prolonged Strenuous Treadmill Exercise on Bronchoalveolar System in Rats

장시간의 고강도 트레드밀 운동이 기관지 폐포계에 미치는 유해한 효과

  • Oh, Kyoung-Mo (Department of Physical Education, Graduate School, Pukyong Natoinal University) ;
  • Hyun, Kyung-Yae (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kim, Chi-Young (Department of Dental Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Choi, Seok-Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Shin, Koon-Soo (Department of Physical Education, Graduate School, Pukyong Natoinal University)
  • 오경모 (부경대학교 대학원 체육학과) ;
  • 현경예 (부산가톨릭대학교 보건과학대학 임상병리학과) ;
  • 김치영 (부산가톨릭대학교 보건과학대학 치기공학과) ;
  • 최석철 (부산가톨릭대학교 보건과학대학 임상병리학과) ;
  • 신군수 (부경대학교 대학원 체육학과)
  • Published : 2009.10.30
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Abstract

We designed this study to investigate the effects of continuous strenuous aerobic exercise on the respiratory system in a rat model. After exercise for 8 weeks, rats' weights were higher in the exercise groups than in the Control group (non-exercise). Rats in Exercise-120 min group (Ex-120 group) had the lowest weights. Total leukocyte counts in bronchoalveolar lavage fluid (BALF) were higher in exercise groups than in Control group. The Ex-30 and Ex-120 groups had higher neutrophil counts, whereas that in the Ex-60 group was lower than in the Control group, and that in the Ex-30 group was the highest. Lymphocyte and monocyte counts were higher in all exercise groups than in the Control group, and those in the Exercise-120 min group were the highest. Interleukin-6 (IL-6) level was the highest, while IL-10, interferon-$\gamma$ and nitric oxide (NO) levels were the lowest in the Ex-120 group when compared to the Control and other exercise groups. These findings suggest that strenuous aerobic exercise for short periods (30 min) may have a beneficial effect on decrease in body weight, whereas prolonged-strenuous aerobic exercise (>1 hr) may be adverse to leukocyte and immune levels in the bronchoalveolar system, as well as result in an increased production of oxygen free radicals.

본 연구는 장시간의 고강도 트레드밀 운동이 호흡기계의 생리를 가장 잘 반영하는 기관지 폐포계에 미치는 생리학적 효과를 규명하기 위해 실시되었다. 랫트를 대상으로 매일 8주간 운동시킨 결과 60분 및 120분 운동 그룹군은 대조군(비운동군)과 30분 운동군보다 체중이 유의하게 낮았으며 운동전보다 체중증가율도 높지 않았다. 기관지 폐포세척액 내 총 백혈구수는 세 운동군(30분, 60분, 120분) 모두 대조군보다 유의하게 높았다. 호중구수는 대조군에 비해 30분군과 120분군은 유의하게 증가하였고 60분군은 감소하였으며 30분군이 가장 높았다. 림프구수는 세 운동군 모두 대조군에 비해 유의하게 높았고 120분군이 가장 높았다. 대식세포(단구) 수는 세군 모두 대조군보다 높았고 120군이 가장 높았다. 기관지폐포액 내 인터루킨-6 농도는 대조군보다 30분군은 낮았고 60분과 120분군은 높았다. 그러나 인터루킨-10과 인터페론 감마 농도는 세 운동군 모두 대조군에 비해 유의하게 낮았다. 산화질소(nitric oxide) 농도는 세 운동군 모두 대조군보다 유의하게 높았다. 본 연구의 결과들은 1시간 이상의 고강도 트레드밀 운동은 기관지 폐포 내 백혈구 분포도에 변화를 유도하고 염증성 사이토카인 및 산화성질소 농도의 증가와 항염증성 사이토카인 농도의 감소와 같은 유해한 효과를 일으킬 수 있음을 시사하고 있다.

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