Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-inflammatory, antinociceptive and diuretic activities of Trema orientalis Linn

  • Uddin, Sarder Nasir (Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University) ;
  • Yesmin, Mst Nazma (Department of Botany, Govt. B. L. College, National University) ;
  • Pramanik, M.K. (Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University) ;
  • Akond, Ma (Department of Botany, Jahangirnagar University)
  • Published : 2009.12.31
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Abstract

The pharmacological interest coupled with traditional uses (antidiarrhoeal, antiseptic, analgesic etc) prompted us to test for anti-inflammatory, antinociceptive and diuretic activitities of Trema (T.) orientalis Linn. The crude methanolic leaves extract of T. orientalis was investigated for its possible anti-inflammatory activities using carrageenin induced rat paw edema model and cotton pellet implantation method in mice. Then the extract analyzed for its antinociceptive activities by acetic acid induced writhing model in mice. The extract possessed significant anti-inflammatory activity in both models at the doses of 200 and 400 mg/kg body weight of mice. Moreover, the extract showed significantly reduced the number of acetic acid-induced abdominal constriction in mice of 200 and 400 mg/kg body weight. The extract also showed positive diuretic activity in albino mice.

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References

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