Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Novel Deposition Method of PLGA Nanoparticles on Coronary Stents

  • Joo, Jae-Ryang (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Nam, Hye-Yeong (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Nam, So-Hee (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Baek, In-Su (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Pakr, Jong-Sang (School of Chemistry & Molecular Engineering, Seoul National University)
  • Published : 2009.05.20
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Abstract

Bare metal stents which were used to treat coronary artery disease have several biochemical problems. Polymerbased drug-eluting stents (DES) have opened up a new paradigm in the treatment of in-stent restenosis. Many studies and research programmes have proved that DES can prevent restenosis. In our study, paclitaxel-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles have been deposited along the three dimensional scaffold of coronary stents by a method using self-assembling properties of colloidal particles. We found that the nanoparticles were deposited uniformly and closely packed. The amount of paclitaxel was easily controlled by the drug content of the nanoparticles and the deposition count.

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References

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