Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Stereoselective Recognition of Amino Alcohols and Amino Acids by Carbonylurea- and Carbonyguanidinium-based Imine Receptors

  • Nandhakumar, Raju (Bio-Chiral Lab, Department of Chemistry and Nano Sciences, Ewha Womans University) ;
  • Ahn, Yun-Soo (Bio-Chiral Lab, Department of Chemistry and Nano Sciences, Ewha Womans University) ;
  • Yoon, Hoe-Jin (Bio-Chiral Lab, Department of Chemistry and Nano Sciences, Ewha Womans University) ;
  • Kim, Kwan-Mook (Bio-Chiral Lab, Department of Chemistry and Nano Sciences, Ewha Womans University)
  • Published : 2009.12.20
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Abstract

New receptors 1-3 that bind stereoselectively amino alcohols and convert chirality of amino acidsvia imine bond formation were synthesized. The receptors have uryl (1), thiouryl (2) and guanidinium (3) groups all with additional phenylcarbonyl motifs, which are effective hydrogen bonding donors and play a key role in the stereoselective recognitions. The stereoselectivities were measured from the integration of $^1HNMR$ peaks. Compound 1 and 2 showed the stereoselectivities for the imine formation with amino alcohols ($K_R/K_S$) in the range of 2${\sim}$4, and compound 3 in the range of 4${\sim}$8. Chirality conversion efficienciesof 1-3 for amino acids, i.e. D/L ratio at equilibrium, are in the range of 1.5${\sim}$5.6, showing a little higher efficiency with 3. The additional phenylcarbonyl motifs in 1-3 were revealed not to contribute to significant enhancement of the selectivities.

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