Bulletin of the Korean Chemical Society

  • 제30권1호
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  • Pages.163-171
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  • 2009
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Stereoselective Synthesis of Diverse α-Hydroxy-β-amino Acids and It's Application for Synthesis of Dipeptide Expecting as a Protease Inhibitor

  • Jang, Sang-Hun (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Kim, Ju-Young (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Kim, Min-Kyu (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Han, Jeong-Woo (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Park, Ki-Hun (Department of Agricultural Chemistry and Division of Applied Life Science, Gyeongsang National University) ;
  • Yoon, Yong-Jin (Department of Chemistry and Research Institute of Natural Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Lee, Sang-Gyeong (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University)
  • 발행 : 2009.01.20
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초록

Few $\alpha$-Hydroxy-$\beta$-amino acids were synthesized via various nucleophilic addition of the epoxide and followed by stereoselective nucleophilic substitution reaction and eliminative cleavage of the acetal selectively in diacetal compound. One of the synthesized $\alpha$-Hydroxy-$\beta$-amino acid reacted with L-leucine methylester to give corresponding dipeptide in good yields.

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참고문헌

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피인용 문헌

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  2. -β-Amino-α-Hydroxy Esters via Dynamic Kinetic Resolution of β-Amino-α-Keto Esters vol.15, pp.10, 2013, https://doi.org/10.1021/ol4009206
  3. -Sulfinyl Imines: Application to the Synthesis of the HCV Protease Inhibitor Boceprevir vol.78, pp.2, 2013, https://doi.org/10.1021/jo301856f
  4. ChemInform Abstract: Stereoselective Synthesis of Diverse α-Hydroxy-β-amino Acids (VII) and Its Application for Synthesis of Dipeptide (VIII) Expecting as a Protease Inhibitor. vol.40, pp.28, 2009, https://doi.org/10.1002/chin.200928169