Bulletin of the Korean Chemical Society

  • 제30권8호
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  • Pages.1767-1770
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  • 2009
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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TMEDA Catalyzed Henry (Nitroaldol) Reaction under Metal and Solvent-free Conditions

  • 발행 : 2009.08.20
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초록

The Henry (nitroaldol) reaction proceeds under mild conditions with catalytic amount of tetramethylethylenediamine (TMEDA) to afford $\beta$-nitro alkanol in considerably excellent yield. Structurally diverse aldehydes react with nitromethane in presence of 0.3 equiv of TMEDA under solvent-free condition at rt. The low catalytic loading and mild reaction condition are the key features of the catalytic method.

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참고문헌

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피인용 문헌

  1. Biocatalytic Approaches to the Henry (Nitroaldol) Reaction vol.2012, pp.16, 2012, https://doi.org/10.1002/ejoc.201101840
  2. Resolution of 2-nitroalcohols by Burkholderia cepacia lipase-catalyzed enantioselective acylation vol.34, pp.1, 2012, https://doi.org/10.1007/s10529-011-0754-x
  3. The Henry Reaction in [Bmim][PF6]-based Microemulsions Promoted by Acylase vol.18, pp.11, 2013, https://doi.org/10.3390/molecules181113910
  4. ) metal–organic framework derived from a flexible amido tripodal acid vol.44, pp.22, 2015, https://doi.org/10.1039/C4DT03087G
  5. Catalytic insertion of aldehydes into dihalonitroacetophenones via sequential bond scission-aldol reaction-acyl transfer vol.52, pp.17, 2016, https://doi.org/10.1039/C5CC09753C
  6. Organocatalytic Insertion of Isatins into Aryl Difluoronitromethyl Ketones vol.82, pp.2, 2017, https://doi.org/10.1021/acs.joc.6b02704
  7. A new sustainable protocol for the synthesis of nitroaldol derivatives via Henry reaction under solvent-free conditions vol.7, pp.1, 2014, https://doi.org/10.1080/17518253.2014.893028
  8. ChemInform Abstract: TMEDA Catalyzed Henry (Nitroaldol) Reaction under Metal and Solvent-Free Conditions. vol.40, pp.51, 2009, https://doi.org/10.1002/chin.200951064
  9. Zinc metal–organic frameworks: efficient catalysts for the diastereoselective Henry reaction and transesterification vol.43, pp.21, 2009, https://doi.org/10.1039/c4dt00219a