Bulletin of the Korean Chemical Society

  • 제30권1호
  • /
  • Pages.43-48
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  • 2009
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Biological Evaluation of Decursin, Prantschimgin and Their Derivatives

  • Xia, Yan (Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Min, Kyung-Hoon (College of Pharmacy, Chung-Ang University) ;
  • Lee, Kyeong (Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology)
  • 발행 : 2009.01.20
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초록

The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

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참고문헌

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