Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of OnDam-TanghapChongMyoung-Tang and DoDam-TanghapChongMyoung-Tang on Protecting Microglia and Inhibiting Acetylcholinesterase and Oxidants

온담탕합총명탕(溫膽湯合聰明湯)과 도담탕합총명탕(導痰湯合聰明湯)의 microglia 보호, 항산화 및 acetylcholinesterase 억제효과

  • Cheong, Myong-Hee (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Jung, In-Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
  • 정명희 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2008.10.25
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Abstract

This experiment was designed to investigate the effect of the ODTCMT and DDTCMT extract on protecting microglia and inhibiting acetylcholinesterase and oxidants. The effects of the ODTCMT and DDTCMT extract on cell death of BV2 microglial cell line treated by $IFN-{\gamma}$ ; expression of NO, ROS in BV2 microglial cell line treated by lipopolysaccharide (LPS) ; AChE activity in PC-12 cell treated by NGF were investigated, respectively. The ODTCMT and DDTCMT extract significantly increased cell viability in BV2 microglial cell line treated with $IFN-\nu$. The ODTCMT and DDTCMT extract suppressed the NO and RDS production in BV2 microglial cell line treated by LPS. The ODTCMT and DDTCMT extract groups also showed inhibition of AChE activity in PC-12 cell line. According to the above result, it is suggested that the ODTCMT and DDTCMT extract might be usefully applied for prevention and treatment of Alzheimer's disease. OnDam-TanghapChongMyoung-Tang (ODTCMT), DoDam-TanghapChongMyoung-Tang (DDTCMT), Microglia, acetylcholinesterase, ROS

Keywords

References

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