Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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An Association Between Apolipoprotein E ${\varepsilon}4$ and Cognitive Function in Community-Dwelling Elders with Questionable Dementia

일 지역사회거주 치매의심 노인에서 Apolipoprotein E ${\varepsilon}4$와 인지기능 간의 연관성

  • Moon, Seok Woo (Department of Neuropsychiatry, School of Medicine Kunkuk University, Chungju Hospital) ;
  • Seo, Jeong Seok (Department of Neuropsychiatry, School of Medicine Kunkuk University, Chungju Hospital) ;
  • Nam, Beom Woo (Department of Neuropsychiatry, School of Medicine Kunkuk University, Chungju Hospital) ;
  • Choi, Jin Young (Department of Neurology, School of Medicine Kunkuk University, Chungju Hospital) ;
  • Lee, Chang Hoon (Department of Laboratory Medicine, School of Medicine Kunkuk University, Chungju Hospital) ;
  • Park, Kyoung Un (Department of Laboratory Medicine, Seoul National University College of Medicine, Bundang Hospital) ;
  • Kim, Ki Woong (Department of Neuropsychiatry, Seoul National University College of Medicine, Bundang Hospital)
  • 문석우 (건국대학교 의학전문대학원 충주병원 정신과학교실) ;
  • 서정석 (건국대학교 의학전문대학원 충주병원 정신과학교실) ;
  • 남범우 (건국대학교 의학전문대학원 충주병원 정신과학교실) ;
  • 최진영 (건국대학교 의학전문대학원 충주병원 신경과학교실) ;
  • 이창훈 (건국대학교 의학전문대학원 충주병원 진단검사의학과학교실) ;
  • 박경운 (서울대학교 의과대학 분당병원 진단검사의학과학교실) ;
  • 김기웅 (서울대학교 의과대학 분당병원 정신과학교실)
  • Published : 2008.02.29
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Abstract

Objectives : It was the aim of the present paper to examine the impact of the apolipoprotein E(APOE) ${\varepsilon}4$ on cognitive performance in community-dwelling elderly samples with 'questionable dementia'. Methods : Total 295 samples who were diagnosed with 'questionable dementia' in the recent year and completed the Korean version of the Consortium Establish a Registry for Alzheimer's Disease(CERAD-K) neuropsychological assessment protocol, were recruited. The CDR test established score of 0.5. Genomic DNA was extracted from the venous blood and APOE genotyping was done in this group. Their cognitive performance was compared by the occurrence of the APOE ${\varepsilon}4$ allele. Results : The impact of ${\varepsilon}4$ allele was significant in the Word List Recall Test(WLRT, F=4.511, df=1, p=0.035). The 'young-old' group aged 75 years and under had a significantly lower performance on the Word List Recall Test(WLRT, F=5.090, df=1, p=0.015), but the 'old-old' group over 75 years of age had not significantly different performance on the all the item of tests in ${\varepsilon}4$+ allele group. Conclusion : The conclusion to be drawn here is that community-dwelling elderly samples with ${\varepsilon}4$ allele in 'questionable dementia' had a significantly lower performance on the Word List Recall Test in the CERAD-K neuropsychological test batteries and the effect was prominent in the 'young-old' age group.

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