한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제16권5호
  • /
  • Pages.326-331
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  • 2008
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지

강화사자발쑥의 마크로파지 RAW 264.7세포에 대한 Tumor Necrosis Factor-$\alpha$, Prostaglandin $E_2$, Cyclooxygenase-2 및 LPS 유도 Nitric Oxide 생성 저해

Extracts of Artemisia princeps Pampanini Inhibit Lipopolysaccharide-induced Nitric Oxide, Cyclooxygenase-2, Prostaglandin $E_2$, and Tumor Necrosis Factor-$\alpha$ Production from Murine Macrophage RAW 264.7 Cells

  • 윤준용 (건국대학교 의료생명대학 생명과학부) ;
  • 최세영 (건국대학교 의료생명대학 생명과학부) ;
  • 박표잠 (건국대학교 의료생명대학 생명과학부) ;
  • 정해곤 (강화농업기술연구센터) ;
  • 신흥묵 (동국대학교 한의과대학 생리학 교실) ;
  • 석경호 (경북대학교 의과대학 약리학교실) ;
  • 임병우 (건국대학교 의료생명대학 생명과학부)
  • Yun, Jun-Yong (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Choi, Se-Yong (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Park, Pyo-Jam (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Chung, Hae-Gon (Ganghwa Agricultural Development & Technology Center) ;
  • Shin, Heung-Mook (Department of Physiology, College of Oriental Medicine, Dongguk University) ;
  • Suk, Kyoung-Ho (Department of Pharmacology, Kyungpook National University School of Medicine) ;
  • Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
  • 발행 : 2008.10.30
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초록

To search for immunoactive natural products exerting anti-inflammatory activity, we have evaluated the effects on the water extracts of Artemisia princeps Pampanini (APP) on lipopolysaccharide-induced nitric oxide (NO), tumor necrosis factor-$\alpha$ (TNF-$\alpha$), and prostaglandin $E_2$ ($PGE_2$) production by RAW 264.7 macrophage cell line. Our data indicate that this extract is a potent inhibitor of NO production and it also significantly decreased PGE2 and TNF-$\alpha$ production. Consistent with these results, the protein and mRNA expression level of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) was inhibited by water extracts of APP in a dose-dependent manner. These results suggest that APP may exert anti-inflammatory and analgesic effects possibly by suppressing the inducible NO synthase and COX-2 expressions.

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