생명과학회지 (Journal of Life Science)

  • 제18권10호
  • /
  • Pages.1336-1341
  • /
  • 2008
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
DOI QR코드

DOI QR Code

신선초의 물 추출물에 의한 천식 증상의 감소

Amelioration of Asthmatic-Related Symptoms by an Aqueous Extract of Angelica archangelica L.

  • 허진철 (경북대학교 식품생물산업연구소 및 식품공학과) ;
  • 이상한 (경북대학교 식품생물산업연구소 및 식품공학과)
  • Heo, Jin-Chul (Food & Bio-Industry Research Institute, and Department of Food Science & Biotechnology Kyungpook National University) ;
  • Lee, Sang-Han (Food & Bio-Industry Research Institute, and Department of Food Science & Biotechnology Kyungpook National University)
  • 발행 : 2008.10.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

기관지를 통하여 발병하는 염증은 대표적인 면역질환의 현상인데 천식이나 아토피 피부염 등에 나타난다. 신선초의 물 추출물이 항천식 활성을 나타내는지를 알아보기 위하여 ovalbumin으로 유도시킨 동물모델을 사용하였다. 마우스에 경구투여하여 폐의 조직을 Haematoxylin-Eosin 염색과 면역조직화학을 이용하여 인터루킨-4 및-13의 발현을 측정한 결과, 신선초의 물 추출물은 $CD4^+$ 세포의 수 및, 인터루킨-4 및 -13의 발현을 억제하는 것으로 나타났다. 이의 결과는 신선초의 물 추출물이 ovalbumin 으로 유도시킨 마우스의 천식 증상을 경감시키는 것으로 이의 활용이 기대된다.

Inflammation through the respiratory tract is a crucial event in immune disorders, including asthma, and atopic rhinitis. To investigate whether an aqueous extract of Angelica archangelica L. (AaL) has a beneficial influence in terms of anti-asthmatic activity, its effects on an ovalbumin-induced asthmatic model were examined. Mice sensitized to ovalbumin were orally administered the AaL extract, and their lungs examined by Haematoxylin-Eosin staining to determine IL-4/13 cytokine expression. The AaL extract exerted strong anti-asthmatic effects by regulating each level in the $CD4^+$ cell number, IL-4/13, and other target markers in the lungs. Together, these results collectively indicate that the aqueous AaL extract ameliorates asthmatic symptoms effectively in a mouse ovalbumin-challenge model.

키워드

참고문헌

  1. Aruoma, O. I. 2003. Methodological considerations for characterizing potential antioxidant actions of bioactive components in plant foods. Mutat. Res. 523-524, 9-20. https://doi.org/10.1016/S0027-5107(02)00317-2
  2. Bast, A., G. R. Haenen and C. J. Doelman. 1991. Oxidants and antioxidants: state of the art. Am. J. Med. 91, 2S-13S.
  3. Choi, J. H., S. W. Oh, M. S. Kang, H. J. Kwon, G. T. Oh and D. K. Kim. 2005. Trichostatin A attenuates airway inflammation in mouse asthma model. Clin. Exp. Allergy 35, 89-96. https://doi.org/10.1111/j.1365-2222.2004.02006.x
  4. Falkeholm, L., C. A. Grant, A. Magnusson and E. Moller. 2001. Xylene-free method for histological preparation: a multicentre evaluation. Lab. Invest 81, 1213-1221. https://doi.org/10.1038/labinvest.3780335
  5. Greene, L. S. 1995. Asthma and oxidant stress: nutritional, environmental, and genetic risk factors. J. Am. Coll. Nutr. 14, 317-324. https://doi.org/10.1080/07315724.1995.10718516
  6. Heo, J. C., S. W. Woo, M. A. Kweon, J. Y. Park, H. K. Lee, M. Son, J. R. Rho and S. H. Lee. 2008. Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo. Int. J. Mol. Med. 21, 57-61.
  7. Huang, D., B. Ou and R. L. Prior. 2005. The chemistry behind antioxidant capacity assays. J. Agr. Food Chem. 53, 1841-1856. https://doi.org/10.1021/jf030723c
  8. Hwang, Y. K., J. S. Chun, P. D. Yoo, J. Y. Ma, B. H. Hyun, S. U. Kim, K. T. Chang and S. H. Lee. 2004. Occlusal reduction of unilateral molars influences change of stress-related hormones in rats. Scand. J. Lab. Anim. Sci. 31, 73-77.
  9. Kim, D. Y., S. Y. Ryu, J. E. Lim, Y. S. Lee and J. Y. Ro. 2007. Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model. Eur. J. Pharmacol. 557, 76-86. https://doi.org/10.1016/j.ejphar.2006.11.027
  10. Lee, E., K. Ha, J. M. Yook, M. H. Jin, C. S. Seo, K. H. Son, H. P. Kim, K. H. Bae, S. S. Kang, J. H. Son and H. W. Chang. 2006. Anti-asthmatic activity of an ethanol extract from Saururus chinensis. Biol. Pharm. Bull. 29, 211-215. https://doi.org/10.1248/bpb.29.211
  11. Lopes, D., H. Strobl and P. Kolodziejczyk. 2004. 14-Methylpentadecano-15-lactone (muscolide): a new macrocyclic lactone from the oil of Angelica archangelica L. Chem. Biodivers. 1, 1880-1887. https://doi.org/10.1002/cbdv.200490144
  12. Mak, J. C. and M. M. Chan-Yeung. 2006. Reactive oxidant species in asthma. Curr. Opin. Pulm. Med. 12, 7-11. https://doi.org/10.1097/01.mcp.0000198067.50457.71
  13. Matsubara, K., H. Matsumoto, M. Iushinal, M. Mori, N. Nakajima, M. Fuchigami, H. Yoshida and H. Hada. 2005. Inhibitory effect of glycolipids from spinach on in vitro and ex vivo angiogenesis. Oncol. Rep. 14, 157-160.
  14. Piersen, C. E. 2003. Phytoestrogens in botanical dietary supplements: implications for cancer. Integr. Cancer Ther. 2, 120-138. https://doi.org/10.1177/1534735403002002004
  15. Ponikau, J. U., D. A. Sherris, G. M. Kephart, E. B. Kern, T. A. Gaffey, J. E. Tarara and H. Kita. 2003. Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma? J. Allergy Clin. Immunol. 112, 877-882. https://doi.org/10.1016/j.jaci.2003.08.009
  16. Rahman, I., S. K. Biswas and A. Kode. 2006. Oxidant and antioxidant balance in the airways and airway diseases. Eur. J. Pharmacol. 533, 222-239. https://doi.org/10.1016/j.ejphar.2005.12.087
  17. Riedl, M. A. and A. E. Nel. 2008. Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr. Opin. Allergy Clin. Immunol. 8, 49-56. https://doi.org/10.1097/ACI.0b013e3282f3d913
  18. Sarker, S. D. and L. Nahar. 2004. Natural medicine: the genus Angelica. Curr. Med. Chem. 11, 1479-500. https://doi.org/10.2174/0929867043365189
  19. Sigurdsson, S., H. M. Ogmundsdottir and S. Gudbjarnason. 2005. Antitumour activity of Angelica archangelica leaf extract. In Vivo 19, 191-194.
  20. Sigurdsson, S., H. M. Ogmundsdottir and S. Gudbjarnason. 2005. The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L. Anticancer Res. 25, 1877-1880.
  21. Striz, I., T. Mio, Y. Adachi, R. A. Robbins, D. J. Romberger and S. I. Rennard. 1999. IL-4 and IL-13 stimulate human bronchial epithelial cells to release IL-8. Inflammation 23, 545-555. https://doi.org/10.1023/A:1020242523697
  22. Wu, A. Y., S. C. Chik, A. W. Chan, Z. Li, K. W. Tsang and W. Li. 2003. Anti-inflammatory effects of high-dose montelukast in an animal model of an acute asthma. Clin. Exp. Allergy 33, 359-366. https://doi.org/10.1046/j.1365-2222.2003.01615.x
  23. Yeh, M. L., C. F. Liu, C. L. Huang and T. C. Huang. 2003. Hepatoprotective effect of Angelica archangelica in chronically ethanol-treated mice. Pharmacology 68, 70-73. https://doi.org/10.1159/000069530

피인용 문헌

  1. Comparison of the toxicity of aqueous and ethanol fractions of Angelica keiskei leaf using the eye irritancy test vol.4, pp.5, 2012, https://doi.org/10.3892/etm.2012.677
  2. Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei vol.5, pp.1, 2013, https://doi.org/10.3892/etm.2012.782