이차성 자연기흉 환자의 재발양상에 관한 분석

Clinical Analysis of Disease Recurrence for the Patients with Secondary Spontaneous Pneumothorax

  • 류경민 (단국대학교 의과대학 흉부외과학교실) ;
  • 김삼현 (단국대학교 의과대학 흉부외과학교실) ;
  • 서필원 (단국대학교 의과대학 흉부외과학교실) ;
  • 박성식 (단국대학교 의과대학 흉부외과학교실) ;
  • 류재욱 (단국대학교 의과대학 흉부외과학교실) ;
  • 김현정 (단국대학교 의과대학 흉부외과학교실)
  • Ryu, Kyoung-Min (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dankook University) ;
  • Kim, Sam-Hyun (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dankook University) ;
  • Seo, Pil-Won (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dankook University) ;
  • Park, Seong-Sik (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dankook University) ;
  • Ryu, Jae-Wook (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dankook University) ;
  • Kim, Hyun-Jung (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dankook University)
  • 발행 : 2008.10.05

초록

배경: 기저폐질환이 없이 늑막하 폐기포의 파열에 의해 발생되는 원발성 자연 기흉 환자들과는 달리, 이차성 자연 기흉 환자들은 다양한 기저폐질환을 가지고 있으며, 재발의 빈도나 그에 따른 치료방침이 다르다. 본 연구는 이차성 자연기흉으로 입원치료를 시행한 환자들에 대하여 재발의 빈도 및 양상, 그리고 치료방법에 대한 결과에 대하여 알아보고자 하였다. 대상 및 방법: 2005년 3월부터 2007년 3월까지 초발한 이차성 자연기흉 환자 85명을 대상으로 치료방법, 재발양상, 재발에 영향을 미치는 인자들에 대하여 후향적으로 의무기록을 분석하였다. 결과: 이차성 자연기흉의 기저질환으로는 폐결핵이 49.4%로 가장 많았으며, 만성폐쇄성 폐질환이 27.6%였다. 평균 $21.1{\pm}6.7$개월($0{\sim}36$개월)의 추적기간 동안 40명의 환자가 재발하여 재발율은 47.1%였으며, 3회 재발율은 10.9%, 4회 재발율은 3.5%였다. 재발기간은 1년이내 재발한 경우가 70.5%였다 치료 성공율은 흥강삽관술만으로 47.6%, 흉관을 통한 흉막유착술 74.4%, 기낭절제수술 71%, Heimlich도관거치 50%로 흉막유착술의 성공율이 가장 높았다. 재발에 영향을 미치는 인자는 7일 이상의 공기누출이었다(p=0.002). 결론: 초발한 이차성 자연기흉 환자에서 7일 이상 공기뉴출이 되는 경우는 재발의 위험성이 높았다. 흉막유착술은 이차성 기흉환자의 재발방지에 유용한 치료방법이나, 앞으로 보다 많은 환자들을 대상으로 표준화된 치료지침의 개발이 필요하겠다.

Background: Secondary spontaneous pneumothorax is caused by various underlying lung diseases, and this is despite that primary spontaneous pneumotherax is caused by rupture of subpleural blebs. The treatment algorithm for secondary pneumothorax is different from that for primary pneumothorax. We studied the recurrence rate, the characteristics of recurrence and the treatment outcomes of the patients with secondary spontaneous pneumothorax. Material and Method: Between March 2005 to March 2007, 85 patients were treated for their first episodes of secondary spontaneous pneumothorax. We analyzed the characteristics and factors for recurrence of secondary spontaneous pneumothorax by conducting a retrospective review of the medical records. Result: The most common underlying lung disease was pulmonary tuberculosis (49.4%), and the second was chronic obstructive lung disease (27.6%), The recurrence rate was 47.1% (40/85). The second and third recurrence rates were 10.9% and 3.5%, respectively. The mean follow up period was $21.1{\pm}6.7$ months (range: $0{\sim}36$ month). For the recurrence cases, 70.5% of them occurred within a year after the first episode. The success rates according to the treatment modalities were thoracostomy 47.6%, chemical pleurodesis 74.4%, blob resection 71% and Heimlich valve application 50%. Chemical pleurodesis through the chest tube was the most effective method of treatment. The factor that was most predictive of recurrence was 'an air-leak of 7 days or more' at the first episode. (p=0.002) Conclusion: The patients who have a prolonged air-leak at the first episode of pneumothorax tend to have a higher incidence of recurrence. Further studies with more patients are necessary to determine the standard treatment protocol for secondary spontaneous pneumothorax.

키워드

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