Clean Technology (청정기술)

The Korean Society of Clean Technology (한국청정기술학회)
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Solubility of Triclosan in Supercritical Carbon Dioxide and its Application to Micronization Process

초임계이산화탄소내 트리클로산의 용해도와 미세입자 제조공정의 응용

  • Shin, Moon-Sam (School of Chemical and Biological Engineering, Seoul National University) ;
  • Kim, Hwa-Yong (School of Chemical and Biological Engineering, Seoul National University)
  • 신문삼 (서울대학교 화학생물공학부) ;
  • 김화용 (서울대학교 화학생물공학부)
  • Published : 2008.09.30
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Abstract

The solubility of triclosan, an anti-acne agent was measured in supercritical carbon dioxide ($scCO_2$) with a variable volume view cell at 313.15, 323.15, and 333.15 K and at pressures between 10 and 40 MPa. We successfully correlated triclosan solubility in $scCO_2$ using the quasi-chemical nonrandom lattice fluid (QLF) equation of state. Triclosan was micronized using the rapid expansion of supercritical solutions (RESS) process. The effects of temperature and pressure on particle size were investigated using phase behavior data and correlated results from the QLF model.

여드름 치료제인 트리클로산의 초임계이산화탄소에 대한 용해도를 가변부피셀(Variable volume cell)을 이용하여 온도 313.15, 323.15와 333.15 K에 대해서 10 - 40 MPa 압력범위에서 측정되었다. QLF (Quasi-chemical nonrandom lattice fluid) 상태방정식을 이용하여 측정된 용해도를 잘 계산할 수 있었고, 이 자료를 미세입자공정에 활용하였고. 입자크기에 미치는 온도와 압력의 효과를 해석하였다.

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