Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Effect of Oral Probiotics (Bifidobacterium lactis AD011 and Lactobacillus acidophilus AD031) Administration on Ovalbumin-Induced Food Allergy Mouse Model

  • Kim, Ji-Yeun (Department of Food and Nutrition, Research Institute of Human Ecology, College of Human Ecology, Seoul National University) ;
  • Choi, Young-Ok (Department of Food and Nutrition, Research Institute of Human Ecology, College of Human Ecology, Seoul National University) ;
  • Ji, Geun-Eog (Department of Food and Nutrition, Research Institute of Human Ecology, College of Human Ecology, Seoul National University)
  • Published : 2008.08.31
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Abstract

Recent study has demonstrated an increasing prevalence of food allergy in Korean children. Specific probiotic bacteria may promote potentially anti-allergenic processes through induction of Th1-type immunity and enhance the regulatory lymphocyte. This study investigated whether orally administrated probiotics could suppress allergic responses in an ovalbumin (OVA)-induced allergy mouse model. Thus, female C3H/HeJ mice were orally sensitized with OVA and cholera toxin for 4 weeks. Lactobacillus acidophilus AD031, Bifidobacterium lactis AD011, and L. acidophilus AD031 plus B. lactis AD011 were fed to mice from 2 weeks before the sensitization. The OVA-induced mice that were not treated with probiotics had significantly increased serum levels of OVA-specific IgE and IgG1, and OVA-specific IgA in feces. However, the mice treated with probiotics suppressed production of the OVA-specific IgE, IgG1, and IgA. The level of IL-4 was significantly lower, and the levels of INF-$\gamma$ and IL-10 were significantly higher in the mice treated with probiotics than that in the non-treated mice. The groups treated with probiotics had decreased levels of degranulated mast cells, eosinophil granules, and tail scabs. These results indicate that L. acidophilus AD031 and B. lactis AD011 might be useful for the prevention of allergy.

Keywords

References

  1. Abu-Ghazaleh, R. I., T. Fujisawa, J. Mestecky, R. A. Kyle, and G. J. Gleich. 1989. IgA-induced eosinophil degranulation. J. Immunol. 142: 2393-2400
  2. Benner, R. H. and F. J. Savelkoul. 1991. Regulation of IgE production in mice. Eur. Respir. J. 13(Suppl): 97-104
  3. Bufford, J. D. and J. E. Gern. 2005. The hygiene hypothesis revisited. Immunol. Allergy Clin. North Am. 25: 247-262 https://doi.org/10.1016/j.iac.2005.03.005
  4. Chehade, M. and L. Mayer. 2005. Oral tolerance and its relation to food hypersensitivities. J. Allergy Clin. Immunol. 115: 3-12 https://doi.org/10.1016/j.jaci.2004.11.008
  5. Christie, L., R. J. Hine, J. G. Parker, and W. Burks. 2002. Food allergies in children affect nutrient intake and growth. J. Am. Diet. Assoc. 102: 1648-1651 https://doi.org/10.1016/S0002-8223(02)90351-2
  6. Eder, W. and E. von Mutius. 2004. Hygiene hypothesis and endotoxin: What is the evidence? Curr. Opin. Allergy Clin. Immunol. 4: 113-117 https://doi.org/10.1097/00130832-200404000-00008
  7. Frossard, C. P., L. Steidler, and P. A. Eigenmann. 2007. Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization. J. Allergy Clin. Immunol. 119: 952-959 https://doi.org/10.1016/j.jaci.2006.12.615
  8. Fuller, R. 1989. Probiotics in man and animals. J. Appl. Bacteriol. 66: 365-378 https://doi.org/10.1111/j.1365-2672.1989.tb05105.x
  9. Hogan, S. P. and A. Mishra. 2001. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat. Immunol. 2: 353-360 https://doi.org/10.1038/86365
  10. Kelly, K. J. 2000. Eosinophilic gastroenteritis. J. Pediatr. Gastroenterol. Nutr. 30(Suppl): 28-35 https://doi.org/10.1097/00005176-200001001-00005
  11. Kim, H. Y., S. Y. Lee, and G. E. Ji. 2005. Timing of Bifidobacterium influences the development of allergy to ovalbumin in mice. Biotechnol. Lett. 227: 1361-1367
  12. Kim, H., K. Kwack, D. Y. Kim, and G. E. Ji. 2005. Oral probiotic bacterial administration suppressed allergic responses. in an ovalbumin-induced allergy mouse model. FEMS Immunol. Med. Microbiol. 45: 259-267 https://doi.org/10.1016/j.femsim.2005.05.005
  13. Kim, N. J. and G. E. Ji. 2006. Modulatory activity of Bifidobacterium sp. BGN4 cell fractions on immune cells. J. Microbiol. Biotechnol. 16: 584-589
  14. Marinaro, M., P. N. Boyaka, F. D. Finkelman, H. Kiyono, R. J. Jackson, E. Jirillo, and J. R. McGhee. 1997. Oral but not parenteral interleukin-12 redirects T helper 2-type responses to an oral vaccine without altering mucosal IgA responses. J. Exp. Med. 185: 415-427 https://doi.org/10.1084/jem.185.3.415
  15. Matsuzaki, T., R. Yamazaki, S. Hashimoto, and T. Yokokura. 1998. The effect of oral feeding of Lactobacillus casei strain Shirota on immunoglobulin E production in mice. J. Dairy Sci. 81: 48-53 https://doi.org/10.3168/jds.S0022-0302(98)75549-3
  16. Mosmann, T. R. and R. L. Coffman. 1989. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv. Immunol. 46: 111-147 https://doi.org/10.1016/S0065-2776(08)60652-5
  17. Oh, J. W., B. Y. Pyun, J. T. Chong, K. M. Ahn, C. H. Kim, S. W. Song, J. A. Son, S. Y. Lee, and S. I. Lee. 2004. Epidemiological change of atopic dermatitis and food allergy in school-aged children in Korea between 1995 and 2000. J. Korean Med. Sci. 19: 716-723 https://doi.org/10.3346/jkms.2004.19.5.716
  18. Ohno, H., S. Tsunemine, Y. Isa, M. Shimakawa, and H. Yamamura. 2005. Oral administration of Bifidobacterium bifidum G9-1 suppresses total and antigen specific immunoglobulin E production in mice. Biol. Pharm. Bull. 28: 1462-1466 https://doi.org/10.1248/bpb.28.1462
  19. Ouwehand, A. C. 2007. Antiallergic effect of probiotics. J. Nutr. 137: 794S-797S https://doi.org/10.1093/jn/137.3.794S
  20. Park, M. S., M. J. Kim, and G. E. Ji. 2007. Assessment of lipopolysaccharide binding activity of Bifidobacterium and its relationship with cell surface hydrophobicity, autoaggregation and inhibition of interleukin-8 production. J. Microbiol. Biotechnol. 17: 1120-1126
  21. Rook, G. A. W. and L. R. Brunet. 2005. Microbes, immunoregulation, and the gut. Gut 54: 317-320 https://doi.org/10.1136/gut.2004.053785
  22. Saldanha, J. C. S., D. L. Gargiulo, S. S. Silva, F. H. Carmo-Pinto, M. C. Andrade, J. I. Alvarez-Leite, M. M. Teixeira, and D. C. Cara. 2004. A model of chronic IgE-mediated food allergy in ovalbumin-sensitized mice. Braz. J. Med. Biol. Res. 37: 809-816 https://doi.org/10.1590/S0100-879X2004000600005
  23. Salminen, S., C. Bouley, M. C. Boutron-Ruault, J. H. Cummings, A. Franck, G. R. Gibson, E Isolauri, M. C. Moreau, M. Roberfroid, and I. Rowland. 1998. Functional food science and gastrointestinal physiology and function. Br. J. Nutr. 80: s147-s171 https://doi.org/10.1079/BJN19980108
  24. Sampson, H. A., S. H. Sicherer, and A. H. Birnbaum. 2001. AGA technical review on the evaluation of food allergy in gastrointestinal disorders. Gastroenterology 120: 1026-1040 https://doi.org/10.1053/gast.2001.23031
  25. Samson, H. A. 1999. Food allergy. Part 1: Immunopathogenesis and clinical disorders. J. Allergy Clin. Immunol. 103: 717-728 https://doi.org/10.1016/S0091-6749(99)70411-2
  26. Shida, K., R. Takahashi, E. Iwadate, K. Takamisawa, H. Yasui, T. Sato, S. Habu, S. Hachimura, and S. Kaminogawa. 2002. Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model. Clin. Exp. Allergy 32: 563-570 https://doi.org/10.1046/j.0954-7894.2002.01354.x
  27. Sicherer, S. H. 2002. Food allergy. Lancet 360: 701-710 https://doi.org/10.1016/S0140-6736(02)09831-8
  28. Taylor, A. L., J. A. Dunstan, and S. L. Prescott. 2007. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial. J. Allergy Clin. Immunol. 119: 184-191 https://doi.org/10.1016/j.jaci.2006.08.036
  29. Torii, A., S. Torii, S. Fujiwara, H. Tanaka, N. Inagaki, and H. Nagai. 2007. Lactobacillus acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines. Allergol. Int. 56: 293-301 https://doi.org/10.2332/allergolint.O-06-459