Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제34권2호
  • /
  • Pages.113-118
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  • 2008
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

악관절환자에서 Synovial fluid에 대한 단백질체 분석에 관한 연구

THE ANALYSIS OF SYNOVIAL FLUID BY PROTEOMICS FROM TMD

  • 변은선 (서울대학교 치과대학 교정학교실) ;
  • 김태우 (서울대학교 치과대학 교정학교실) ;
  • 김상균 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 박태일 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 박준우 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 윤필영 (분당서울대학교병원 치과 구강악안면외과) ;
  • 김영균 (분당서울대학교병원 치과 구강악안면외과) ;
  • 채창훈 (나노큐어텍 나노-바이오 퓨전 부설연구소)
  • Byun, Eun-Sun (Dept. of Orthodontics, College of Dentistry, Seoul National University) ;
  • Kim, Tae-Woo (Dept. of Orthodontics, College of Dentistry, Seoul National University) ;
  • Kim, Sang-Gyun (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Park, Tae-Il (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Park, Jun-Woo (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Yun, Pil-Young (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital) ;
  • Kim, Young-Kyun (Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital) ;
  • Chae, Chang-Hoon (Institute of Nano-Bio Fusion Technology, NanoCureTech Inc.)
  • 발행 : 2008.04.30
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초록

Temporomandibular joint disorder (TMD) can induce severe pain but, its pathogenic mechanisms remain poorly understood. In this study, we analyzed proteomes of human synovial fluid in the superior joint space in the patients with TMD, which is obtained during the treatment arthrocentesis. We've got this result that one of the spots was consistently down-regulated in synovial fluid of patients with TMD from analysis of protein pattern. Its molecular weight was estimated to be 33 kDa. Synoviolin was identified in our proteomics analysis of LC/MS/MS. This protein was recently reported as one of the proteins that might affect rheumatoid arthritis (RA). Synoviolin that might be associated with RA was detected in synovial fluid of patients with TMD. We can conclude that synoviolin might be involved not only in the pathogenesis of RA but also in TMD. In result, synoviolin might be involved in the pathogenesis of TMD and can be candidates as new therapeutic targets of TMD or early detection biomarkers.

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참고문헌

  1. Poveda Roda R, Diaz Fernandez JM, Hernandez Bazan S, Jimenez Soriano Y, Margaix M, Sarrion G: A review of temporomandibular joint disease (TMJD). Part II: Clinical and radiological semiology. Morbidity processes. Med Oral Patol Oral Cir Bucal 20081;13(2):E102-9
  2. Li Z, Li ZB, Li JR: Surgical management of posttraumatic temporomandibular joint ankylosis by functional restoration with disk repositioning in children. Plast Reconstr Surg 2007 Apr 1;119(4):1311-6 https://doi.org/10.1097/01.prs.0000254550.75633.60
  3. Mah J: Histochemistry of the foetal human temporomandibular joint articular disc. Eur J Orthod 2004 Aug;26(4):359-65 https://doi.org/10.1093/ejo/26.4.359
  4. Stamm T, Hohoff A, Van Meegen A, Meyer U: On the three-dimensional physiological position of the temporomandibular joint. J Orofac Orthop 2004 Jul;65(4):280-9 https://doi.org/10.1007/s00056-004-0402-3
  5. Uyanik JM, Murphy E: Evaluation and management of TMDs, Part 1. History, epidemiology, classification, anatomy, and patient evaluation. Dent Today 2003 Oct;22(10):140-5
  6. Desmons S, Graux F, Atassi M, Libersa P, Dupas PH: The lateral pterygoid muscle, a heterogeneous unit implicated in temporomandibular disorder: a literature review. Cranio 2007 Oct;25(4):283-91. Review https://doi.org/10.1179/crn.2007.042
  7. Ellis E, Throckmorton GS: Treatment of mandibular condylar process fractures: biological considerations. J Oral Maxillofac Surg 2005 Jan;63(1):115-34. Review
  8. Politi M, Toro C, Cian R, Costa F, Robiony M: The deep subfascial approach to the temporomandibular joint. J Oral Maxillofac Surg 2004 Sep;62(9):1097-102 https://doi.org/10.1016/j.joms.2003.10.013
  9. Lafreniere CM, Lamontagne M, el-Sawy R: The role of the lateral pterygoid muscles in TMJ disorders during static conditions. Cranio. 1997 Jan;15(1):38-52
  10. Kim SJ et al.: The presence of bacteria in the synovial fluid of the temporomandibular joint and clinical significance: preliminary study. J Oral maxillofac Surg 2002;60;1156-1161
  11. Wiesend M, Kanehl S, Esser E: [Arthrocentesis--a highly efficient therapy for acute TMJ arthropathy]. Mund Kiefer Gesichtschir 2006 Sep;10(5):341-6 https://doi.org/10.1007/s10006-006-0011-y
  12. Ethunandan M, Wilson AW: Temporomandibular joint arthrocentesis- more questions than answers? J Oral Maxillofac Surg 2006 Jun;64(6):952-5 https://doi.org/10.1016/j.joms.2006.02.012
  13. Yura S, Totsuka Y: Relationship between effectiveness of arthrocentesis under sufficient pressure and conditions of the temporomandibular joint. J Oral Maxillofac Surg 2005 Feb;63(2):225-8 https://doi.org/10.1016/j.joms.2004.06.053
  14. Trieger N, Hoffman CH, Rodriguez E: The effect of arthrocentesis of the temporomandibular joint in patients with rheumatoid arthritis. J Oral Maxillofac Surg 1999 May;57(5):537-40 https://doi.org/10.1016/S0278-2391(99)90070-8
  15. Jae-Jin Kim: The effect of intra-articular injection of hyaluronic acid after arthrocentesis in treatment of internal derangements of the TMJ. J Kor Oral Maxillofac Surg 2006 Oct;032(05):453-457
  16. Amano T, Yamasaki S, et al.: Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev 17: 2436-2449 https://doi.org/10.1101/gad.1096603
  17. Naoko Yagishita. et al.: Essential Role of Synoviolin in Embryogenesis. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;Vol. 280, No. 9, Issue of March 4, pp. 7909-7916 https://doi.org/10.1074/jbc.M410863200
  18. Satoshi Yamasaki. et al.: Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. The EMBO Journal (2007) 26, 113-122 https://doi.org/10.1038/sj.emboj.7601490
  19. Kaneyuki Tsuchimochi. et al.: Identification of a Crucial Site for Synoviolin Expression. MOLECULAR AND CELLULAR BIOLOGY, Aug. 2005, Vol. 25, No. 16.p. 7344-7356 https://doi.org/10.1128/MCB.25.16.7344-7356.2005
  20. Myew-Ling Toh, Hubert Marotte, Jean-Luc Blond, Umar Jhumka, Assia Eljaafari, Bruno Mougin, and Pierre Miossec: Overexpression of Synoviolin in Peripheral Blood and Synoviocytes From Rheumatoid Arthritis Patients and Continued Elevation in Nonresponders to Infliximab Treatment. ARTHRITIS & RHEUMATISM. Vol. 54, No. 7, July 2006, pp 2109-2118 https://doi.org/10.1002/art.21926
  21. Satoshi Yamasaki, Naoko Yagishita, Kaneyuki Tsuchimochi, Kusuki Nishioka and Toshihiro Nakajima. Rheumatoid arthritis as a hyperendoplasmic reticulumassociated degradation disease. Arthritis Research & Therapy 2005, 7:181-186 https://doi.org/10.1186/ar1808
  22. Kusuki Nishioka, et al.: Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic. Genes & Dev. 2003;17:2436-2449 https://doi.org/10.1101/gad.1096603
  23. Beixue Gao, Karen Calhoun and Deyu Fang: The proinflammatory cytokines IL-1${\beta}$ and TNF-${\alpha}$ induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway. Arthritis Research & Therapy 2006, 8:R172 https://doi.org/10.1186/ar2081
  24. Cecilia P Chung, Annette Oeser, Ingrid Avalos, Tebeb Gebretsadik, Ayumi Shintani, Paolo Raggi, Tuulikki Sokka, Theodore Pincus1 and C Michael Stein: Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis. Arthritis Research & Therapy 2006, 8:R186 https://doi.org/10.1186/ar2098