Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

THE CHANGE OF THE TEMPOROMANDIBULAR JOINT AFTER EXPERIMENTAL DISTRACTION OF MANDIBULAR RAMUS IN RABBIT

가토에서 하악골 신장술이 악관절에 미치는 영향

  • Lim, Seung-Kyu (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
  • Kim, Chul-Hwan (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
  • Kim, Kyung-Wook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
  • 임승규 (단국대학교 치과대학 구강악안면외과학교실) ;
  • 김철환 (단국대학교 치과대학 구강악안면외과학교실) ;
  • 김경욱 (단국대학교 치과대학 구강악안면외과학교실)
  • Published : 2008.10.31
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Abstract

Distraction osteogenesis is a commonly used technique for mandibular lengthening, but changes in the temporomandibular joint(TMJ) have not been well documented. The TMJ is one of the most complex joint in the body and is composed of a fibrous surface layer, a proliferative zone, hypertrophic cartilage, and bone. The shape and role of the TMJ change and modify during a person's life-time. Possible complications that can arise after mandibular distraction include failure of the formation, failure of callus, infection, disturbance of TMJ and of occlusion. However, there are only a few reports on changes in the TMJ as a result of distraction osteogenesis. Hence, the goal of this study was to evaluate the change of the TMJ after experimental distraction of mandibular ramus in rabbit. We studied histological changes of mandibular condyle, articular disk and retrodiscal tissue, and also examined the collagen I gene expression and MMP-1 gene expression. The results were as follows. 1. In the histological staining, experimental condylar surface showed more thick fibrous articular layer and proliferative layer, compared with the control condyle and experimental articular disc showed thick and dense collagen fibers compared with the control disc. 2. In the collagen I and MMP-1 gene RT-PCR analysis, experimental discs showed increased collagen I expression compared with the control disc, while MMP-1 gene expression was decreased compared with the control disc. The retrodiscal tissue was almost equal expressions of the collagen I and MMP-1 genes compared with the control retrodiscal tissue. These findings suggest that histological and biomolecular changes occur in condyles and discs after unilateral mandibular distraction osteogenesis.

Keywords

References

  1. Codvilla A : On the means of lengthening the lower limbs, The muscles and tissues which are shortened through deformity, Am J Orthop Surg 1905;2:353-369
  2. Ilizarov GA : Basic principles of transosseous compression and distraction osteogenesis. Orthop Tranumatol Protez 1971;32:7- 15
  3. Illizarov GA : The tension-stress effect on the genesis and growth of tissue: part 1, The influence of stability of fixation and soft tissue preservation. Clin.Orthop 1989;238:249-281
  4. llizarov GA : The tension-stress effect on the genesis and growth of tissue: part 2, The influence of the rate and frequency of distraction. Clin. Orthop 1989;239:263-285
  5. Synder CC, Levine GA, Swanson HM : Mandibular lengthening by gradual distraction. Preliminary report. Plas Reconstr Surg 1973;51:506-508 https://doi.org/10.1097/00006534-197305000-00003
  6. McCarthy J : Plastic Surgery. Craniofacial Microsomia. Vol. 4. Philadelphia, WB Saunders Co., 1990
  7. 권경환, 민승기, 오승환, 이 준, 차재원 : 외과적 하악 정중부 골신장술, 대한구강악안면외과학회지 2004; 30: 516-525
  8. McCarthy JG : The role of distraction osteogenesis in the reconstruction of the mandible in unilateral craniofacial microsomia. Clin Plast Surg 1994 ;21:625
  9. 권준경, 박홍주, 유선열 : 가토의 하악골에서 골신장기 동안 반복 골신장술이 골형성에 미치는 효과. 대한구강악안면외 과학회지 2006; 32: 241-249
  10. 조영철, 성일용, 변준호, 박봉욱, 김욱규, 신상훈, 김종렬 : 성 견의 골신장술에서 골절단술시 재조합 인간 골형성 단백질-7 적용에 따른 가골반응과 Osteocalcin 발현도에 대한 연구. 대 한구강악안면외과학회지 2006;32:317-326
  11. Block MS, Otten J, McLaurin D : Bifocal distraction osteogenesis for mandibular defect healing: Case report. J Oral Maxillofac Surg 1996;54:1365-1370 https://doi.org/10.1016/S0278-2391(96)90499-1
  12. 백성문, 김수관, 김학균, 문성용 : 반안면 왜소증 환자에서의 골신장술. 대한구강악안면외과학회지 2007;33:559-566
  13. Polley JW, Figueroa AA, Charbel FT : Monobloc craniomaxillofacial distraction osteogenesis in a newborn with severe craniofacial synostosis: a preliminary report. J Craniofac Surg. 1995;6:421-3 https://doi.org/10.1097/00001665-199509000-00022
  14. Murray JE, Kaban LB and Mulliken JB : Analysis and treatment of hemifacial microsomia. Plast Reconstr Surg 1984;74:186-99 https://doi.org/10.1097/00006534-198408000-00003
  15. Karp NS, Thorne CH, McCarthy JG : Bone lengthening in the craniofacial skeleton. Ann Plastic Surg 1990;24: 231-237 https://doi.org/10.1097/00000637-199003000-00007
  16. Paley D : Problems, obstacles, and complications of limb lengthening by the Ilizarov technique. Clin Orthop 1990;250:81-87
  17. Karaharju-Suvanto T, Peltonen J, Kahri A : Distraction osteogenesis of the mandible: An experimental study on sheep. J Oral Maxillofac Surg 1992;21:118-124 https://doi.org/10.1016/S0901-5027(05)80547-8
  18. Karp NS, McCarthy JG, Schreiber JS : Membranous bone lengthening: A serial histologic study. An Plast Surg 1992;29:2-9 https://doi.org/10.1097/00000637-199207000-00002
  19. Block MS, Daire J, Stover J : Changes in the inferior alveolar nerve following mandibular lengthening in the dog using distraction osteogenesis. J Oral Maxillofac Surg 1993;51:652-659 https://doi.org/10.1016/S0278-2391(10)80265-4
  20. Aronson J, Harp JH : Mechanical forces as predictors of healing during tibial lengthening by distraction osteogenesis. Clin Orthop 1994;301:73-81
  21. Troulis MJ, Perrott, DH, Kaban LB : Endoscopic mandibular osteotomy, and placement and activation of a semiburied distractor. J Oral Maxillofac Surg 1999;57:1110-1119 https://doi.org/10.1016/S0278-2391(99)90335-X
  22. Troulis MJ, Glowacki J, Perrott DH : Effects of latency and rate on bone formation in a porcine mandibular distraction model. J Oral Maxillofac Surg 2000;58:507-512 https://doi.org/10.1016/S0278-2391(00)90012-0
  23. Castaňo FJ, Troulis MJ, Glowacki J : Proliferation of masseter myocytes after distraction osteogenesis of the porcine mandible. J Oral Maxillofac Surg 2001;59:302-310 https://doi.org/10.1053/joms.2001.21000
  24. Costantino PD, Shybut G, Friedman CD : Segmental mandibular regeneration by distraction osteogenesis. Arch Otolaryngol Head Neck Surg 1990;116:535-541 https://doi.org/10.1001/archotol.1990.01870050035003
  25. Aronson J, Shen X: Experimental healing of distraction osteogenesis comparing metaphyseal with diaphyseal sites. Clin Orthop Rel Res 1994;301: 25-29
  26. Ten Cate AR : The temporomandibular joint, St louis, Mosby, 1985
  27. Copray J, Jansen H and Dyterloo HS : Effects of compressive forces on proliferation and matrix synthesis in mandibular condylar cartilage of the rat in vitro, Archs Oral Biol 1985;30:299-304 https://doi.org/10.1016/0003-9969(85)90001-9
  28. Copray J, Jansen H and Duterloo HS : An in-vitro system for studying the effect of variable compressive forces on the mandibular condylar cartilage of the rat, Archs Oral Biol 1985;30:305-311 https://doi.org/10.1016/0003-9969(85)90002-0
  29. Stewart KJ, Lvoff GO, White SA l: Mandibular distraction osteogenesis: A comparison of distraction rates in the rabbit model. J Craniomaxillofac Surg 1998;26:43-51 https://doi.org/10.1016/S1010-5182(98)80034-6
  30. Greg F and Joseph E : Long-Term Effect of Mandibular Midline Distraction Osteogenesis on the Status of the Temporomandibular Joint, Teeth, Periodontal Structures and Neurosensory Function Oral Maxiiiofac Surg 1999;57:1419- 1425 https://doi.org/10.1016/S0278-2391(99)90723-1
  31. Mankin HJ : Current concepts review The response of articular cartilage to mechanical injury, J Bone and Joint Surg 1982;64:460-6 https://doi.org/10.2106/00004623-198264030-00022
  32. McNamara Jr JA, Hinton RJ and Hoffman DL : Histologic analysis of temporomandibular joint adaptation to protrusive function in young adult rhesus monkeys(macaca mulatta), Am J Orthod 1986;82:288-98 https://doi.org/10.1016/0002-9416(82)90463-8
  33. Petra T, Maria J, Andrew R : Changes in the Condyle and Disc in Response to Distraction Osteogenesis of the Minipig Mandible J Oral Maxillofac Surg 2002;60:1327-33 https://doi.org/10.1053/joms.2002.35733
  34. Samcbukov ML, Cope JB, Harper RP : Biomechanical considerations of mandibular lengthening and widening by gradual distraction using a computer model, J Oral Maxillofac Surg 1998;56:51- 9 https://doi.org/10.1016/S0278-2391(98)90916-8
  35. Nakamura E, Mizuta H, Sei A : Knee articular cartilage injury in leg lengthening ; histologic studies in rabbits, Acta Orthop Scand 1993;64:437-40 https://doi.org/10.3109/17453679308993662
  36. Nakai H, Niimi A and Ueda M : The influence of compressive loading on growth of cartilage of the mandibular condyle in vitro, Archs Oral Biol 1998;43:505-15 https://doi.org/10.1016/S0003-9969(98)00041-7
  37. Gloria A, Shawn M, Jarmo K : Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen J. Biol. Chem. 2002;277:4223-31
  38. Karsenty G and Park RW : Regulation of type I collagen genes expression. Int Rev Immunol 1995;12: 177-85 https://doi.org/10.3109/08830189509056711
  39. Karl H, Andrew W and Arin H : Matrix Remodeling Expression in Anulus Cells Subjected to Increased Compressive Load. 2005;30:1122-26 https://doi.org/10.1097/01.brs.0000162395.56424.53
  40. Gross J and Lapiere C : Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci U S A 1962; 48:1014-22
  41. Eisen A, Jeffrey J and Gross J : Human skin collagenase. Isolation and mechanism of attack on the collagen molecule. Biochim Biophys Acta 1968;151:637-45 https://doi.org/10.1016/0005-2744(68)90010-7
  42. Remacle AG, Rozanov DV, Fugere M : Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP. Oncogene. 2006;25:5648-5655 https://doi.org/10.1038/sj.onc.1209572