YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Salicylate Enhances Insulin Signaling by Preventing Ser731 Phosphorylation of Insulin Receptor Substrate 1

Insulin Receptor Substrate 1의 세린731 인산화 억제를 통한 살리실산의 인슐린저항성 개선효과 기전

  • Lee, Yong-Hee (Department of Biochemistry, College of Medicine, Chungbuk National University)
  • 이용희 (충북대학교 의과대학 생화학교실)
  • Published : 2008.06.30
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Abstract

Salicylate (SA) was shown to alleviate insulin resistance. Here, we showed that SA inhibited Ser731 phosphorylation of insulin receptor substrate 1 (IRS1) and S6 kinase activation, and enhanced tyrosine phosphorylation of IRS1 in response to insulin or amino acid. Experiments using a cJun N-terminal kinase (JNK)-deficient cell and an IRS1 JNK-binding mutant showed that JNK is not required for Ser731 phosphorylation. A two-week treatment of obese mice with SA resulted in decreased Ser731 phosphorylation and enhanced insulin signaling. These results suggest that SA enhances insulin signaling by inhibiting Ser731 phosphorylation of IRS1.

Keywords

References

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