The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 29 Issue 1
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- Pages.243-257
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- 2008
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- 1226-9174(pISSN)
Effect of Differentiation for Mouse Myoblast $C_{2}C_{12}$ Cells against Myostatin expression from Dodamtang
도담탕(導痰湯)이 $C_{2}C_{12}$ 세포주로부터 myostatin발현에 의한 심근에 미치는 영향
- Lee, You-Seung (Dept. of Internal Medicine, College of Oriental Medicine, Daegu-Haany University) ;
- Shin, Yoo-Jeong (Dept. of Internal Medicine, College of Oriental Medicine, Daegu-Haany University) ;
- Park, Jong-Hyuk (Dept. of Internal Medicine, College of Oriental Medicine, Daegu-Haany University) ;
- Kim, Seung-Mo (Dept. of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Daegu-Haany University) ;
- Paek, Kyung-Min (Dept. of Internal Medicine, College of Oriental Medicine, Daegu-Haany University) ;
- Park, Chi-Sang (Dept. of Internal Medicine, College of Oriental Medicine, Daegu-Haany University)
- 이유승 (대구한의대 내과학교실) ;
- 신유정 (대구한의대 내과학교실) ;
- 박종혁 (대구한의대 내과학교실) ;
- 김승모 (대구한의대 심계내과학교실) ;
- 백경민 (대구한의대 내과학교실) ;
- 박치상 (대구한의대 내과학교실)
- Published : 2008.03.31
Abstract
Myostatin, a negative regulator of myogenesis, is shown to function by controlling the proliferation of myoblasts. In this study we show that myostatin is an inhibitor of myoblast differentiation and that this inhibition is mediated through Smad 3. To determine MyoD expression by Dodamtang treatment, we compared the expression pattern of