The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 29 Issue 1
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- Pages.189-199
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- 2008
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- 1226-9174(pISSN)
Effect of Jichul-hwan on Gastric Motility in Conscious and Gastric Wall Injured Rats
지출환(枳朮丸)의 흰쥐 위(胃) 운동성(運動性)에서 정상 상태 및 위벽 국소손상 후에 대한 효능
- Lee, Seung-Woo (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Yoon, Sang-Hyub (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
- Published : 2008.03.31
Abstract
Background & Objective : Jichul-hwan(JCH) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. We investigated the effects of JCH on gastric motility and its mechanisms of action in rats. Methods : The gastric wall was injured by tracting a part of stomach body in rats. Gastric emptying was measured after administration of normal saline(NS) or JCH in normal rats and gastric wall injured rats. To evaluate the mechanism of JCH under delayed gastric emptying conditions, normal rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kgg, i.p.),