대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권1호
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- Pages.117-129
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- 2008
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- 1226-9174(pISSN)
내소산(內消散)의 정상 및 위 유문부 확장 흰 쥐의 위 운동성에 대한 효능
Effect of Naeso-san on Gastric Motility between Normal Intact and Antral Dilatated Rats
- Kim, Jin-Seok (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Yoon, Sang-Hyub (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
- 발행 : 2008.03.31
초록
Background & Objective : Naeso-san(NSS) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. A main cause of gastric dysmotility is antral dilatation or antroduodenal uncoordination. Therefore, we investigated the effect of NSS on gastric motility and its mechanism of action, as well as the morphologic changes in antral dilatated rats. Methods : Antral dilatated rats were induced by wrapping a nonabsorbable rubber ring(D:6mm, W:4mm, T:1mm) around the 1st portion of the duodenum for 8 weeks. Then morphologic changes were investigated and compared with normal intact rats before and after 8 weeks. Gastric emptying was measured by administration of normal saline(NS) or NSS in normal intact and antral dilatated rats. In another series of experiments to evaluate the mechanism of NSS under delayed conditions, normal intact rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kg, i.p.),