The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 29 Issue 1
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- Pages.117-129
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- 2008
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- 1226-9174(pISSN)
Effect of Naeso-san on Gastric Motility between Normal Intact and Antral Dilatated Rats
내소산(內消散)의 정상 및 위 유문부 확장 흰 쥐의 위 운동성에 대한 효능
- Kim, Jin-Seok (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Yoon, Sang-Hyub (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
- Published : 2008.03.31
Abstract
Background & Objective : Naeso-san(NSS) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. A main cause of gastric dysmotility is antral dilatation or antroduodenal uncoordination. Therefore, we investigated the effect of NSS on gastric motility and its mechanism of action, as well as the morphologic changes in antral dilatated rats. Methods : Antral dilatated rats were induced by wrapping a nonabsorbable rubber ring(D:6mm, W:4mm, T:1mm) around the 1st portion of the duodenum for 8 weeks. Then morphologic changes were investigated and compared with normal intact rats before and after 8 weeks. Gastric emptying was measured by administration of normal saline(NS) or NSS in normal intact and antral dilatated rats. In another series of experiments to evaluate the mechanism of NSS under delayed conditions, normal intact rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kg, i.p.),