대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권1호
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- Pages.12-24
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- 2008
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- 1226-9174(pISSN)
LPS로 유발된 대식세포의 염증반응에 대한 청상보하탕(淸上補下湯)의 효과
Effect of Chungsangboha-tang on LPS induced Anti-inflammatory in THP-1 cells
- 이경희 (경희대학교 한의과대학 폐계내과학 교실) ;
- 김홍렬 (경희대학교 한의과대학 폐계내과학 교실) ;
- 정희재 (경희대학교 한의과대학 폐계내과학 교실) ;
- 이형구 (경희대학교 한의과대학 폐계내과학 교실)
- Lee, Kyung-Hee (Dept. of (allergy, immunity, respiratory organs) Medicine, Oriental Hospital of Kyung-hee University) ;
- Kim, Hong-yeoul (Dept. of (allergy, immunity, respiratory organs) Medicine, Oriental Hospital of Kyung-hee University) ;
- Jung, Hee-Jae (Dept. of (allergy, immunity, respiratory organs) Medicine, Oriental Hospital of Kyung-hee University) ;
- Lee, Hyung-Koo (Dept. of (allergy, immunity, respiratory organs) Medicine, Oriental Hospital of Kyung-hee University)
- 발행 : 2008.03.31
초록
Background and Objective : Chungsangboha-tang (CSBHT) has analgesic, sedative, anti-convulsive and anti-histamine effects, so it alleviates the symptoms of asthma. For the comparison of anti-inflammatory effect(s) on CSBHT, PD098059 was used as a negative control. Materials and Methods : This study emphasized THP-1 cells, which had been well characterized as a human monocytic leukemic cell line. The cells resemble monocytes with respect to several criteria and can be differentiated into macrophage-like cells by treatment with PMA. By using the MTS assay, it was possible to prove the safety of CSBHT. Results : Results shows that the CSBHT did not affected cell survival within
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