대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권2호
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- Pages.456-468
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- 2008
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- 1226-9174(pISSN)
가미사군자탕(加味四君子湯)이 OVA로 유발된 천식 마우스에 미치는 영향
Effects of Gamisagunja-tang in an Ovalbumin(OVA)-Induced Allergic Asthma in Mice
- Son, Ji-Woo (Department of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
- Shin, Jo-young (Department of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
- Lee, Si-Hyeong (Department of Professional Graduate School of Oriental Medicine Wonkwang University)
- 발행 : 2008.06.30
초록
Objective : The purpose of this study was to investigate the effects of Gamisagunja-tang(GS) on the airway hyper-reactivity (AHR), cytokine production and T cell activation during the ovalbumin (OVA)-induced allergic asthma in mice. Materials and Methods : BALB/c mice were sensitized and challenged with 100 mg of OVA and 1 mg of aluminum potassium sulfate intraperitoneally on days 1 and 7. On day 14, mice were challenged on 3 consecutive days with 5% OVA. AHR and bronchoalveolar fluid (BALF), total inflammatory cell count and the production of cytokines were measured. Results : GS significantly suppressed the infiltration of inflammatory cells in the lung tissue and AHR. GS significantly down regulated the production of IL-4, IL-5 and increases of