DOI QR코드

DOI QR Code

성남시 소재 초등학교 저학년에서 아토피 피부염 환자군과 대조군의 식생활 비교

Comparison of Dietary Behavior between Atopic Dermatitis Patients and Controls in Elementary School Students Living in the Sung-nam Area

  • 신유경 (경희대학교 생활과학대학 식품영양학과) ;
  • 김명희 (경희대학교 교육대학원 영양교육) ;
  • 정자용 (경희대학교 생활과학대학 식품영양학과)
  • Shin, You-Kyung (Department of Food & Nutrition, Kyung Hee University) ;
  • Kim, Myung-Hee (Graduate School of Nutrition Education, Kyung Hee University) ;
  • Chung, Ja-Yong (Department of Food & Nutrition, Kyung Hee University)
  • 발행 : 2008.10.30

초록

The prevalence of atopic dermatitis (AD) in children has increased dramatically in recent years. Although AD has genetic determinants, this rapid increase is most likely due to changes in environmental influences--for example, dietary changes. The purpose of this case-control study was to assess the relationship between the risk of developing AD and dietary factors, including eating habits, food intake, and the consumption of various functional foods in children at ages of 7 or 8 years. 143 AD patients and 335 healthy children participated in this study. A mini-dietary assessment was utilized to evaluate the food intake and dietary patterns of the children, and other information, including demographic and socioeconomic characteristics, eating habits, and the frequency of functional food use was collected using a questionnaire. The results demonstrated that, among the demographic and socioeconomic factors assessed in this study, female gender, mother's employment, and the family history of AD significantly increased the risk of AD. However, no differences in dietary habits and specific food intake between AD patients and healthy controls were identified. On the other hand, the frequencies of taking multivitamin supplements, Spirulina, or gamma-linoleic acid were significantly higher in AD patients than in the controls. These data indicate that alterations in eating habits and the intake of certain foods may not be a critical cause associated with the risk of AD in school-age children, and caution should be taken in recommending food elimination diets for the purpose of preventing AD. Further studies are required in order to determine whether the intake of specific nutrients could contribute to the increase or prevention of the development of AD in school-age children.

키워드

참고문헌

  1. Almqvist C, Pershagen G, Wickman M. 2005. Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. Clin. Exp. Allergy, 35(5):612-618 https://doi.org/10.1111/j.1365-2222.2005.02243.x
  2. Barnetson RSC, Roser M. 2002. Childhood atopic eczema. BMJ., 324(7350):1376-1379 https://doi.org/10.1136/bmj.324.7350.1376
  3. Becker EW, Jakober R, Lufr D, Schmulling RM. 1986. Clinical and biochemical evaluation of the alga Spirulina with regard to its application in the treatment of obesity. a coubleblind crossover study. Nutr. Rep. Int., 33:565-572
  4. Beyer K, Teuber SS. 2005. Food allergy diagnostics: scientific and unproven procedures. Curr. Opin. Allergy Clin. Immunol., 5(3):261-266 https://doi.org/10.1097/01.all.0000168792.27948.f9
  5. Chong SJ, Kim KH, Kim DW, Kim SJ, Kim IJ, Kim CW, et al. 2005. Report from ADRG: A study on the Clinical Manifestations of Childhood Atopic dermatitis in Korea. Korean J. Dermatol., 43(11):1497-1509
  6. Choue RY, Lee EY, Ryu KA, Yim JE, Lee HB, O JW. 2007. Effect of Types of Formulas on the Clinical Symptoms, Nutritional Status Immune Markers in Infants with Atopic Dermatitis . Pediatr. Allergy Respir. Dis., 27(1):33-42
  7. Christie L, Hine RJ, Parker JG, Burks W. 2002. Food allergies in children affect nutrient intake and growth. J. Am. Diet Assoc. 102(11):1648-1651 https://doi.org/10.1016/S0002-8223(02)90351-2
  8. Chung JY, Oh SY, Cho BH. 2007. Prevalence and Dietary Determinants of Atopic Dermatitis among Preschool Children in Metropolitan Area. Korean J. Health Promot.Dis. Prev., 7(2):104-112
  9. Ciferri O. 1983. Spirulina the edible microorgamism. Microbiol. Rev., 47:551-578
  10. Devereux G, Seaton A. 2005. Diet as a risk factor for atopy and asthma. J. Allergy Clin. Immunol. 115(6):1109-1117 https://doi.org/10.1016/j.jaci.2004.12.1139
  11. Eigenmann PA, Sampson HA. 1994. An update on food hepersensitivity. Fund. Clin. Immunol. 2:121-133
  12. Feldman S, Behnam SM, Behnam SE, Koo JYM. 2005. Involving the patient : impact of inflammatory skin disease and patient-focused care. J. Am. Acad. Dermatol., 53:S89-S85 https://doi.org/10.1016/j.jaad.2005.03.006
  13. Fogarty A, Lewis S, Weiss S, Britton J. 2000. Dietary vitamin E, IgE concentrations, and atopy. Lancet., 356(9241):1573-1574 https://doi.org/10.1016/S0140-6736(00)03132-9
  14. Han YS, Chung SJ, Cho YY, Choi HM, Ahn KM, Lee SI. 2004. Analysis of the Rate of Sensitization to Food Allergen in Children with Atopic Dermatitis. Korean J. Community Nutr., 9(1):90-97
  15. Hersoug LG, Benn CS, Simonsen JB, Kamper-Jorgensen M, Linneberg A. 2008. Maternal employment in Childcare institutions and the risk of infant wheeze and atopic dermatitis in the offspring. Pediart. Allergy Immunol., 18:1-8
  16. Hoppu U, Asher MI, Bjorksten P, Lampi AM, Piironen V, Lsolauri E. 2005. Vitamin C in breast milk may reduce the risk of atopic in the infant. Eur. J. Clin. Nutri., 59(1):123-128 https://doi.org/10.1038/sj.ejcn.1602048
  17. Hwang I, Cha A, Lee H, Yoon H, Yoon T, Cho B, Lee S, Park Y. 2007. N-3 polyunsaturated fatty acids and atopy in Korean preschoolers. Lipids, 42(4):345-349 https://doi.org/10.1007/s11745-007-3033-9
  18. Isolauri E. 1995. The treatment of cow's milk allergy. Eur. J. Clin. Nutr., 49:S49-55
  19. Jung JA, Lee JS, Lee SI. 2003. Serum Specific IgE to Egg White, Cow's Milk, Soybean in the Children with Atopic Dermatitis. Pediatr. Allergy Respir. Dis., 13(4):256-262
  20. Kay RA. 1991. Microalgae as food and supplement. Critical Reviews in Food Science & Nutrition, 30(6):555-573 https://doi.org/10.1080/10408399109527556
  21. Kim HY, Park JY. 2003. The effect of spirulina on lipid metabolism, antopcidant capacity and immune function on Korean elderlies. Korean J. Nutr. 36(10):287-297
  22. Kim WY, Cho MS, Lee HS. 2003. Development and Validation of Mini Dietary Assessment Index for Koreans. Korean J. Nutr., 36(1):83-92
  23. Koch C, Dölle S, Metzger M, Rasche C, Jungclas H, Rühl R, Renz H, Worm M. 2008. Docosahexaenoic acid (DHA) supplementation in atopic eczema: a randomized, doubleblind, controlled trial. Br. J. Dermatol., 158(4):786-792 https://doi.org/10.1111/j.1365-2133.2007.08430.x
  24. Koopman LP, Wijga A, Smit HA, De Jongste JC, Kerkhof M, Gerritsen J, Vos AP, Van Strien RT, Brunekreef B, Neijens HJ. 2002. Early respiratory and skin symptoms in relation to ethnic background: the importance of socioeconomic status; the PIAMA study. Arch. Dis. Child., 87(6):482-488 https://doi.org/10.1136/adc.87.6.482
  25. Laughter D, Istvan JA, Tofte SJ, Hanifin JM. 2000. The prevalence of atopic dermatitis in Oregon schoolchildren. J. Am. Acde. Dermatol., 43(4):649-655 https://doi.org/10.1067/mjd.2000.107773
  26. Lee KS, Oh EY, Park JH, Hing CH, Lee SY. 2001. Comparison of child behavior checklist between allergic and non-allergic patients. J. Asthma Allergy Clin. Immuno., 21(2):178-186
  27. Lehtonen EP, Holmberg-Marttila D, Kaila M. 2003. Cumulative prevalence of atopic eczema and related skin symptoms in a well-baby clinic:a retrospective cohort study. 2003. Pediatr. Allergy Immunol., 14(5):405-408 https://doi.org/10.1034/j.1399-3038.2003.00071.x
  28. Leung DY, Diaz LA, Deleo V, Soter NA. 1997. Allergic and immunologic skin disorders. JAMA, 278:1914-1923 https://doi.org/10.1001/jama.278.22.1914
  29. Levy RM, Gelfand JM, Yan AC. 2003. The epidermiology of atopic dermatitis. Clin. Dermatol., 21(2):109-115 https://doi.org/10.1016/S0738-081X(02)00360-7
  30. Lindbaek M, Wefring KW, Grangard EH, Ovsthus K. 2003. Socioeconomical conditions as risk factors for bronchial asthma in children aged 4-5 yrs. Eur. Respir. J., 21(1):105-108 https://doi.org/10.1183/09031936.02.00241802
  31. McNally NJ, Williams HC, Phillips DR. 1998. Atopic eczema and domestic water hardness. Lancet., 352(9127):527-531 https://doi.org/10.1016/S0140-6736(98)01402-0
  32. Miranda MS, Cintra R, Barros SBM, Mancini-Filho J. 1998. Antioxidant activity of the miroalga Spirulina maxima. Brazilian J. Medical and Biological Res., 30:1075-1079
  33. Morren MA, Przybilla B, Bamelis M, Heykants B, Reynaers A, Degreef H. 1994. Atopic dermatitis:triggering factors. J. Am. Acad. Dermatol., 31(3):467-473 https://doi.org/10.1016/S0190-9622(94)70213-6
  34. Novak N, Bieber T. 2003. Allergic and nonallergic forms of atopic diseases. J. Allergy Clin. Immunol., 112:252-262 https://doi.org/10.1067/mai.2003.1595
  35. Oh JW, Kim KE, Pyun BY, Lee HR, Choung JT, Hong SJ, et al. 2003. Nationwide Study for Epidemiological Change of Atopic Dermatitis in School Aged Children between 1995 and 2000 and Kindergarten Aged Children in 2003 in Korea. Pediatr. Allergy Respir. Dis., 13(4):227-237
  36. Osburm L. 1992. Hemp seed: The most nutritionally complete food source in the world, Part II: Hemp seed oils and the flow of life force. Hemp. Line Journal, 1(2):12-13
  37. Park YI. 2000. Isolation and purification of antiallergic substance from spirurina. K. J. Microbiol. Symplsium Book, pp 80-82
  38. Paurene Duramad, Ira B Tager, Nina T Holland. 2007. Cytokines and other immunological biomarkers in children's environmental health studies. Toxicol. Lett., 172(1-2):48-59 https://doi.org/10.1016/j.toxlet.2007.05.017
  39. Pinero Estrada JE, Bermejo Descos P, Villar del Fresno AM. 2001. Antioxidant activity of defferent fractions of Spirurina platensis protean extract. Farmaco., 56(5-7):497-500 https://doi.org/10.1016/S0014-827X(01)01084-9
  40. Reid P, Lewis-Jones MS. 1995. Sleep difficulties and their management in preschoolers with atopic eczema. Clin. Exp. Dermatol., 20(1):38-41 https://doi.org/10.1111/j.1365-2230.1995.tb01280.x
  41. Rhim JW, Moon SK, Kong DY, Pyun BY. 2005. An Investigation into the Actual Condition of Outbreak and Treatment in Atopic Dermatitis. Pediatr. Allergy Respir Dis., 15(1):44-52
  42. Sampson HA, McCaskill CC. 1985. Food hypersensitivity and atopic dermatitis: evaluation of 113 patients. J. Pediatr., 107(5):669-675 https://doi.org/10.1016/S0022-3476(85)80390-5
  43. Shin KY, Park HS, Oh SY. 2006. Analyses on Nutritional and Behavioral Risk Factors of Atopic Dermatitis (AD) in Korean Preschoolers. Korean J. Nutr., 39(8):795-800
  44. Sinagra JL, Bordignon V, Ferraro C, Cristaudo A, Di Rocco M, Amorosi B, Capitanio B. 2007. Unnecessary milk elimination Diets in Children with Atopic dermatitis. Pediatr. Dermatol., 24(1):1-6 https://doi.org/10.1111/j.1525-1470.2007.00382.x
  45. Vickers CFH. 1980. The natural history of atopic eczema. Acta. Derm. Venerol., 92:113-115
  46. Williams H, Robertson C, Stewart A, Aït-Khaled N, Anabwani G, Anderson R, et al. 1999. Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of asthma and allergies in Childhood. J. Allergy. Clin. Immunol., 103(1Pt 1):125-138 https://doi.org/10.1016/S0091-6749(99)70536-1
  47. Williams HC, Strachan DP, Hay RJ. 1994. Childhood eczema: disease of the advantaged? BMJ., 308(6937):1132-1135 https://doi.org/10.1136/bmj.308.6937.1132
  48. Wuthrich B.1996. Epidermiology and natural history of atopic dermatitis. Allergy Clin. Immunol. Int., 8(3):77-82
  49. Wuthrich B. 1998. Food-induced cutaneous adverse reactions. Allergy, 53(46 suppl):131-135 https://doi.org/10.1111/j.1398-9995.1998.tb04983.x
  50. Yoon SP. 1999. The environment and lifestyles of atopic dermatitis patients. Korean J. Dermatol., 37(8):983-991