Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Toxicity of 30 kGy Irradiated Cereal Powders for Three Months

30 kGy 감마선 조사된 곡류 분말의 아급성 독성평가

  • Jeon, Young-Eun (Dept. of Food Science and Nutrition & The Korean Institute of Nutrition, Hallym University) ;
  • Kim, Hye-Mi (Dept. of Food Science and Nutrition & The Korean Institute of Nutrition, Hallym University) ;
  • Lee, Ju-Woon (Division of Radiation Application Research, Korea Atomic Energy Research Institute) ;
  • Byun, Myung-Woo (Division of Radiation Application Research, Korea Atomic Energy Research Institute) ;
  • Kang, Il-Jun (Dept. of Food Science and Nutrition & The Korean Institute of Nutrition, Hallym University)
  • 전영은 (한림대학교 식품영양학과.한국영양연구소) ;
  • 김혜미 (한림대학교 식품영양학과.한국영양연구소) ;
  • 이주운 (한국원자력연구소) ;
  • 변명우 (한국원자력연구소) ;
  • 강일준 (한림대학교 식품영양학과.한국영양연구소)
  • Published : 2008.10.31
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Abstract

In order to evaluate their possible subacute toxicity, the male and female of SD rats were given to 30 kGy irradiated cereal powders for three months. During the experimental periods, appearance, behavior, mortality, body weight, organ weight, and food consumption of rats fed the 30 kGy cereal powders were not affected compared to the non-irradiated control. In urine analysis, histopathological examination, hematological as well as in serum biochemical findings, no significant differences were found between the rats administered with non-irradiated control and 30 kGy cereal powders for three months. These results indicate that cereal powders irradiated at 30 kGy did not show any toxic effects under these experimental conditions.

곡류분말의 위생화 및 물성 개선을 위해 고선량 감마선 조사 기술의 이용 가능성이 높아짐에 따라 이들의 안전성을 확보할 목적으로 30 kGy 고선량 감마선 조사 곡류분말을 대상으로 3개월간 독성 평가를 실시하였다. 30 kGy로 조사한 곡류분말을 3개월간 암수 랫트에 경구 투여한 후 독성을 평가한 결과, 시험기간 동안 시험 물질 투여에 의한 임상 증상이나 폐사 동물은 나타나지 않았으며 체중 변화, 사료 섭취량 및 주요 장기 무게도 대조군에 비해 차이를 보이지않았다. 혈액학적 검사, 혈청학적 검사 및 뇨 검사에서도 모든 시험군은 정상적인 수치를 나타내었다. 병리조직학적 검사에서 간, 신장, 비장 및 위 조직 모두 정상적인 구조를 유지하고 있었으며, 염증, 괴사 등의 유의할만한 병적 변화도 관찰되지 않았다. 따라서 고선량 조사 곡류분말(30 kGy)을 3개월간 암 수 랫트에 5,000 mg/kg까지 섭취시켜도 본 시험조건에서는 독성이 없는 것으로 나타났다.

Keywords

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