Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지
DOI QR코드

DOI QR Code

The Effects of Cirsium japonicum on Lipid Profile in Ovariectomized Rats

  • Kwon, Hyeok-Yi (College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University) ;
  • Rhyu, Mee-Ra (Food Function Research Division, Korea Food Research Institute) ;
  • Lee, Young-Joo (College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University)
  • Published : 2008.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Cirsium japonicum water extracts has been used to treat vascular related diseases. We have previously reported that Cirsium japonicum extracts activated estrogen receptors. It is widely known that estrogen increases the high density lipoprotein cholesterol and decrease the low density lipoprotein cholesterol on the lipid profile. But effects of Cirsium japonicum on lipid profile are not reported yet. Therefore, we have studied the effects of Cirsium japonicum on the lipid content in ovariectomized rats. Thirty Sprague-Dawley (SD) rats of $210{\pm}20\;g$ were studied for 10 weeks. The rats were divided into five groups; (I) sham, no ovariectomized rats plus olive oil, (II) ovariectomized rats plus olive oil, (III) ovariectomized rats plus 0.5 mg/kg $17{\beta}$-estradiol (E2) in olive oil, (IV) ovariectomized rats plus 0.5 mg/kg Cirsium japonicum in olive oil, and (V) ovariectomized rats plus 5 mg/kg Cirsium japonicum in olive oil. Treatment with Cirsium japonicum or E2 induced significant reduction in total cholesterol, low density lipoprotein cholesterol/total cholesterol, total cholesterol/high density lipoprotein cholesterol and low density lipoprotein cholesterol/high density lipoprotein cholesterol compared to control group as well as increase in uterine weight. However, changes in triglycerides levels were different. Our results suggest that Cirsium japonicum is functionally similar to E2 in vivo as well as in vitro.

Keywords

References

  1. Colacurci, N., Chiàntera, A., Fornaro, F., de Novellis, V., Manzella, D., Arciello, A., Chiàntera, V., Improta, L. and Paolisso, G. (2005). Effects of soy isoflavones on endothelial function in healthy postmenopausal women. Menopause. 12, 299-307 https://doi.org/10.1097/01.GME.0000147017.23173.5B
  2. Coope, J. and Marsh, J. Can we improve compliance with long term HRT? (1992). Maturitas. 15, 151-158 https://doi.org/10.1016/0378-5122(92)90249-4
  3. Cornwell, T., Cohick, W. and Raskin, I. (2004). Dietary phytoestrogens and health. Phytochemistry. 65, 995-1016 https://doi.org/10.1016/j.phytochem.2004.03.005
  4. Deroo, B. J. and Korach, K. S. (2006). Estrogen receptors and human disease. J. Clin. Invest. 116, 561-70 https://doi.org/10.1172/JCI27987
  5. Eisenberg, D. M., Davis, R. B., Ettner, S. L., et al. (1998). Trends in alternative medicine use in the United States, 1990-1997. JAMA. 280, 1569-1575 https://doi.org/10.1001/jama.280.18.1569
  6. El-swefy, S. E., Ali, S. I., Asker, M. E. and Mohamed, H. E. (2002). Hyperhomocysteinemia and cardiovascular risk in female ovariectomized rats role of folic acid and hormone replacement therapy. Pharm. Pharmacol. 54, 391-397 https://doi.org/10.1211/0022357021778457
  7. Ganzera, M., Pocher, A. and Stuppner, H. (2005). Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS. Phytochem. Anal. 16, 205-209 https://doi.org/10.1002/pca.846
  8. Gehm, B. D., McAndrews, J. M., Chien, P. Y. and Jameson, J. L. (1997). Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA. 94, 14138-14143 https://doi.org/10.1073/pnas.94.25.14138
  9. Glazier, M. G. and Bowman, M. A. (2001). A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med. 161, 1161-72 https://doi.org/10.1001/archinte.161.9.1161
  10. Harris, D. M., Besselink, E., Henning, S. M., Go, V. L. W. and Heber, D. (2005). Phytoestrogens induce differential estrogen receptor alpha- or beta-mediated responses in transfected breast cancer cells. Exp. Biol. Med. 230, 558-568 https://doi.org/10.1177/153537020523000807
  11. Hodgson, J. M., Puddey, I. B., Beilin, L. J., Mori, T. A., Burke, V., Croft, K. D. and Rogers, P.B. (1999). Effects of isoflavonoids on blood pressure in subjects with high-normal ambulatory blood pressure levels: a randomized controlled trial, Am. J. Hypertens. 12, 47-53
  12. Http://en.wikipedia.org/wiki/cirsium
  13. Http://en.wikipedia.org/wiki/Estrogen
  14. Jayagopal, V., Albertazzi, P., Kilpatrick, E. S., Howarth, E. M., Jennings, P. E., Hepburn, D. A. and Atkin, S. L. (2002). Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care. 25, 1709-1714 https://doi.org/10.2337/diacare.25.10.1709
  15. Kuiper, G.. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B. and Gustafsson, J. A. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor $\beta$. Endocrinology. 139, 4252-4263
  16. Kurzer, M. S. and Xu, X. (1997). Dietary phytoestrogens, Annu Rev Nutr. 17, 353-381 https://doi.org/10.1146/annurev.nutr.17.1.353
  17. Lee, W. B., Kwon, H. C., Cho, O. R., Lee, K. C., Choi, S. U., Baek, N. I. and Lee, K. R. (2002). Phytochemical constituens of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines. Arch. Pharm. Res. 25, 628-635 https://doi.org/10.1007/BF02976934
  18. Mahn, K., Borras, C., Knock, G. A., Taylor, P., Khan, I. Y., Sugden, D., Poston, L., Ward, J. P., Sharpe, R. M., Vina, J., Aaronson, P. I. and Mann, G. E. (2005). Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J. 19, 1755-1757 https://doi.org/10.1096/fj.05-4008fje
  19. Park, M. K., Rhyu, M. R., Yoon, B. K., Kwon, H. Y., Jang. S., Lee, Y. J. (2008). Modulation of the genomic estrogen receptor pathway by water extracts of Cirsium japonicum. Arch Pharm Res. 31, 225-30 https://doi.org/10.1007/s12272-001-1145-y
  20. Ravnikar, V. A. Compliance with hormone replacement therapy. (1987). Am J Obstet Gynecol. 156, 1332-1336 https://doi.org/10.1016/0002-9378(87)90173-6
  21. Rivas, M., Garay, R. P., Escanero, J. F., Cia, P. Jr., Cia, P. and Alda, J. O. (2002). Soy milk lowers blood pressure in men an women with mild to moderate hypertension. J. Nutr. 132, 1900-1902
  22. Setchell, K. D. (1998). Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am. J. Clin. Nutr. 68, 1333S-1346S https://doi.org/10.1093/ajcn/68.6.1333S
  23. Squadrito, F., Altavilla, D., Crisafulli, A., Saitta, A., Cucinotta, D., Morabito, N., D'Anna, R., Corrado, F., Ruggeri, P., Frisina. and Squadrito, G. (2003). Effect of genistein on endothelial function in postmenopausal women: a randomized, doubleblind controlled study. Am. J. Med. 114, 470-476 https://doi.org/10.1016/S0002-9343(03)00059-7
  24. Teede, H. J., McGrath, B. P., DeSilva, L., Cehun, M., Fassoulakis, A. and Nestel, P. J. (2003). Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arterioscler. Thromb. Vasc. Biol. 23, 1066-1071 https://doi.org/10.1161/01.ATV.0000072967.97296.4A
  25. Yim, S. H., Kim, H. J. and Lee, I. S. (2003). A polyacetylene and flavonoids from Cirsium rhinoceros. Arch. Pharm. Res. 26, 128-131 https://doi.org/10.1007/BF02976657

Cited by

  1. Apigenin-7-O-β-D-glucuronide inhibits modified low-density lipoprotein uptake and foam cell formation in macrophages vol.35, 2017, https://doi.org/10.1016/j.jff.2017.06.026
  2. Royal Jelly Increases Collagen Production in Rat Skin After Ovariectomy vol.15, pp.6, 2012, https://doi.org/10.1089/jmf.2011.1888