Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Interleukin-2 Promotes Angiogenesis by Activation of Akt and Increase of ROS

  • Bae, Jin-Hee (School of Biological Sciences, College of Natural Sciences, Kangwon National University) ;
  • Park, Deok-Bum (School of Biological Sciences, College of Natural Sciences, Kangwon National University) ;
  • Lee, Yun-Sil (Laboratory of Radiation Effect, Division of Radiation Biology, Korea Institute of Radiological and Medical Sciences) ;
  • Jeoung, Doo-Il (School of Biological Sciences, College of Natural Sciences, Kangwon National University)
  • Published : 2008.02.29
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Abstract

Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.

Keywords

References

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