Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Anti-diabetic Activity of Polysaccharide from Salicornia herbacea

함초 다당체의 항당뇨 활성

  • Kim, Seon-Hee (Department of Biomedical Laboratory Science and Biohealth Products Research Center, Inje University) ;
  • Ryu, Deok-Seon (Department of Biomedical Laboratory Science and BK21 Smart Food & Drug Center, Inje University) ;
  • Lee, Mi-Young (Department of Biomedical Laboratory Science and Biohealth Products Research Center, Inje University) ;
  • Kim, Ki-Hoon (Department of Biomedical Laboratory Science and BK21 Smart Food & Drug Center, Inje University) ;
  • Kim, Yong-Ho (Department of Biomedical Laboratory Science and Biohealth Products Research Center, Inje University) ;
  • Lee, Dong-Seok (Department of Biomedical Laboratory Science and Biohealth Products Research Center, Inje University)
  • 김선희 (인제대학교 의생명공학대학 임상병리학과, 인제대학교 바이오헬스 소재 연구센터) ;
  • 류덕선 (인제대학교 의생명공학대학 임상병리학과, BK21 식의약생명공학사업단) ;
  • 이미영 (인제대학교 의생명공학대학 임상병리학과, 인제대학교 바이오헬스 소재 연구센터) ;
  • 김기훈 (인제대학교 의생명공학대학 임상병리학과, BK21 식의약생명공학사업단) ;
  • 김용호 (인제대학교 의생명공학대학 임상병리학과, 인제대학교 바이오헬스 소재 연구센터) ;
  • 이동석 (인제대학교 의생명공학대학 임상병리학과, 인제대학교 바이오헬스 소재 연구센터)
  • Published : 2008.03.28
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Abstract

The present study investigated the effect of physiologically active polysaccharide (SP1) isolated from Salicornia herbacea on streptozotocin-induced diabetic rats. Male Spraque-Dawley rats were divided into four groups which were normal control group (NC), diabetic control group (DC), diabetic CSP group (DCSP), and diabetic SP1 group (DSP1). Animals were administrated with 2% experimental drinks for 6 weeks. The levels of glucose, triglyceride, total cholesterol, and high density lipoprotein (HDL)-cholesterol in the serum were measured before and after intake of test compounds. The levels of glucose and triglyceride in the DSP1 were significantly lower than those in the DC by 25% and 20%, respectively. The levels of total cholesterol and high density lipoprotein (HDL)-cholesterol in the DSP1 were similar to those in the DC. These results suggest that SP1 substantially exhibit anti-hyperglycemic and anti-hypertriglyceridemic activity in diabetic rats. Therefore SP1 is believed to show remarkable anti-diabetic effect on streptozotocin-induced diabetic rats.

함초(Salicornia herbacea)는 염습 지대에서 자생하는 명아주과에 속하는 일년초 식물로서 우리말로는 퉁퉁마디라고 불리우며, 식용과 약용으로 이용되고 있다. 건조된 함초로부터 열수 추출을 하여 조추출물(CSP)을 얻었으며 조추출물을 한외 여과하여 다당체(SP1)를 얻었다. 이렇게 얻은 조추출물과 다당체에 대해 streptozotocin (55 mg/mL/kg)으로 유발한 당뇨 쥐를 이용하여 정상 대조군(NC)과 당뇨 대조군(DC), 당뇨 조추출물군(DCSP), 당뇨 다당체군(DSP1)으로 분류하고 각각 조추출물과 다당체 2%를 6주간 공급하여 실험한 결과, DCSP군과 DSP1군에서는 대조군과 비교하여 혈당은 10%, 25%씩 감소하고, 중성 지방은 13%, 20%씩 감소하여 유의적인 수치를 나타내었다. 즉, 함초로부터 조추출물과 다당체를 획득하여 이들에 대한 항당뇨 실험을 한 결과, 조추출물과 다당체에서 혈당 저하와 중성 지방 저하의 효과를 보였는데, 조추출물보다 다당체에서 더 높은 활성을 보였다. 따라서 함초 다당체는 항당뇨 활성을 가진 바이오헬스 소재로 개발될 수 있을 것으로 기대된다.

Keywords

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