The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)
- Volume 21 Issue 3
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- Pages.60-74
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- 2008
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- 1229-4292(pISSN)
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- 2508-3619(eISSN)
Effects of Gwibi-Tang on the Estradiol Valerate-induced Polycystic Ovaries in Rats
귀비탕(歸脾湯)이 Estradiol Valerate로 유도된 흰쥐의 다낭성 난소에 미치는 영향
- Lee, Yeon-Kyeong (Dept. of Oriental Gynecology, College of Oriental Medicine, Se-Myung University) ;
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Seo, Il-Bock
(Dept. of Oriental Gynecology, College of Oriental Medicine, Se-Myung University) ;
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Lee, Dong-Nyung
(Dept. of Oriental Gynecology, College of Oriental Medicine, Se-Myung University) ;
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Kim, Hyung-Jun
(Dept. of Oriental Gynecology, College of Oriental Medicine, Se-Myung University)
- 이연경 (세명대학교 한의과대학 한방부인과교실) ;
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서일복
(세명대학교 한의과대학 한방부인과교실) ;
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이동녕
(세명대학교 한의과대학 한방부인과교실) ;
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김형준
(세명대학교 한의과대학 한방부인과교실)
- Published : 2008.08.30
Abstract
Purpose: This study was designed to investigate the effects of Gwibi-Tang(GBT) on the polycystic ovary(PCO) induced by estradiol valerate(EV) in rats. Methods: PCO was induced by single intramuscular injection with EV(4mg) in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for eight weeks. PCO control group(n=8) were injected with EV and orally administrated distilled water for eight weeks. GBT treated group(n=8) were injected with EV and orally administrated GBT for eight weeks. Then we measured weight of body, ovaries, adrenal glands, and uterus of rats. The histopathology changes of ovaries were also evaluated. The expression of nerve growth factor(NGF) was analyzed in the central nervous system, adrenal glands and ovaries by immunohistochemistry. And also CRF expression in median eminance of Rats were analyzed. Results: 1. The weight(g) of rats in GBT treated group(
Keywords
- polycystic ovary(PCO);
- Gwibi-Tang;
- nerve growth factor(NGF);
- corticotropin releasing factor(CRF);
- estradiol valerate(EV)