Antimicrobial Effect of Flavanones from Sophora flavescens Ait

고삼으로부터 분리된 Flavanones의 항균효과

  • Young, Hee-Tae (Department of Food Nutrition, Daejeon Health Sciences College) ;
  • Choi, Hwa-Jung (Natural Medicine Research Centre, Korea Research Institute of Bioscience & Biotechnology) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 양희태 (대전보건대학 식품영양과) ;
  • 최화정 (생명공학연구원 천연물의약연구센터) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2008.08.31

Abstract

Two known lavandulylated flavanones, leachianone A (1) and sophoroaflavanone G (2), were isolated from the roots of S. flavascens Ait. The structures of these compounds were determined on the basis of IR, 1D and 2D NMR in addition to direct comparison with authentic compounds. However, leachianone A (1) and sophoroflavanone G (2) did not have growth inhibition activity against any microorganisms (MIC, >200 ${\mu}g/ml$).

Keywords

References

  1. Kang, M. H., Lee, J. H., Lee, J. H., Cho, S. Y., Choi, J. S., Kim, Y. S., Kang, S. S. and Jeong, C. S. : Antigastritic and anti Helicobacter pylori of Trifolirhizin from Sophora Radix. Kor. J. Pharmacogn. 37, 266 (2006)
  2. 崔峀邊 : 中藥大全, 黑龍江科學技術出版社, 黑龍江 pp. 279-280 (1989)
  3. 中國醫學科學院 物硏究所 重藥志(梯1冊), 人民衛生出版社, 北京 pp. 193-197 (1979)
  4. Woo, E. R., Kwak, J. H., Kim, H. J. and Park, H. K. : A new prenylated flavonol from the roots of Sophora flavescens. J. Nat. Prod. 61, 1552 (1998) https://doi.org/10.1021/np980103j
  5. 正草 : 中藥學, 人民衛生出版社 北京 pp. 145-147 (1995)
  6. 劉春安 : 彭明 抗暗中草藥大辭典, 湖北科學技術出版社 pp. 607- 612 (1994)
  7. 嚴仲, 李方林 : 中國長白山 藥用 植物 彩色圖志 人民爲生出版 社, 北京 pp. 254-256 (1997)
  8. 李尙仁 : 본초학, 의약사 p. 300 (1975)
  9. 儼仲鐵, 李方林 : 中國長白山藥用植物體色圖志, 人民衛生出版社, 北京 pp. 254 (1997)
  10. 徐國均 : 中國藥材學, 中國醫藥科技出版社, 北京 pp. 252-256 (1996)
  11. Kanaoka, M., Yoshizaki, M. and Fujino, H. : Studies in the constituents of Trichosanthes species, I, Chem. Pham. Bull. 30, 2570 (1982) https://doi.org/10.1248/cpb.30.2570
  12. 김진철, 김미려, 양재하, 최종백 : 고삼이(苦蔘) 당뇨에 미치는 영 향에 관한 실험적 연구. 대구한의대학교 제한동의학술원 (1991)
  13. Kim, Y. C., Kim, H. S., Wataya, Y., Sohn, D. H., Kang, T. H., Kim, M. S., Kim, Y. M., Lee, G. M., Chang, J. D. and Park, H. : Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens. Biol. Pharm. Bull. 27, 748 (2004) https://doi.org/10.1248/bpb.27.748
  14. Son, J. K., Park, J. S., Kim, J. A., Kim, Y., Chung, S. R. and Lee, S. H. : Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 69, 559 (2003) https://doi.org/10.1055/s-2003-40643
  15. Yeo, H. D., Lee, H. C., Lim, B. K., Kim, H. K., Choi, M. S. and Yang, J. K. : Antifungal activity of the quercus mongolica extracts against Botrytis cinerea. Mokchae Konghak 36, 88 (2008)
  16. Choi, W. S., Jang, D. Y., Choi, K. G., Lee, B. H., Kim, T. J. and Jung, B. J. : Synthesis and phytopathogenic activities of isopropylphenyl derivatives. J. korean Soc. Appl. Biol. Chem. 50, 178 (2007)
  17. Busattaa, C., Vidala, R. S., Popiolskia, A. S., Mossia, A. J., Darivab, C., Rodriguesc, M. R. A., Corazzaa, F. C., Corazzaa, M. L., Vladimir Oliveiraa, J. and Cansiana, R. L. : Application of Origanum majorana L. essential oil as an antimicrobial agent in sausage. Food Microbiology 25, 207 (2008) https://doi.org/10.1016/j.fm.2007.07.003
  18. Inuma, M., Tanaka, T., Mizuno, M., Shirataki, Y., Yokoe, I., Komatsu, M. A. and Lang, F. : Two flavanones in sophora leachiano and some related structure. Phytochem. 29, 2667 (1990) https://doi.org/10.1016/0031-9422(90)85209-X
  19. Kim, Y. K., Min, B. S. and Bae, K. H. : A cytotoxic constituent from Sophora flavescens. Arch. Pharm. Res. 20, 342 (1997) https://doi.org/10.1007/BF02976197