Journal of Acupuncture Research
- 제25권3호
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- Pages.41-51
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- 2008
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
자하차약침(紫河車藥鍼)의 MIF 활성 억제를 통한 LPS 유발 류마티스성 관절염의 치료 효과
Effect of Inhibition Macrophage Migration Inhibitory Factor Activation by Hominis Placenta Herbal Acupuncture on Rheumatic Arthritis
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황지혜
(동국대학교 한의과대학 침구학교실) ;
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조현석
(동국대학교 한의과대학 침구학교실) ;
- 이현진 (동국대학교 한의과대학 침구학교실) ;
- 이동건 (동국대학교 한의과대학 침구학교실) ;
- 정원제 (동국대학교 한의과대학 침구학교실) ;
- 정찬영 (동국대학교 한의과대학 침구학교실) ;
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김경호
(동국대학교 한의과대학 침구학교실)
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Hwang, Ji-Hye
(Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
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Cho, Hyun-Seok
(Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
- Lee, Hyun-Jin (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
- Lee, Dong-Gun (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
- Jeong, Won-Je (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
- Jung, Chan-Yung (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
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Kim, Kyung-Ho
(Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University)
- 발행 : 2008.06.20
초록
Objectives : This study is to evaluate Effect of Inhibition Macrophage Migration Inhibitory Factor(MIF) activation by Hominis Placenta Herbal Acupuncture(HPA) on Rheumatic Arthritis(RA). Hominis Placenta is the placenta of healthy human, which is vital-strengthening medical stuff. In recent years, Hominis Placenta applied to chronic diseases because it makes us more resistance to diseases. Therefore it is supposed that HPA is effective on RA, a kind of autoimmune disease. When RA is induced, MIF is activated, too. MIF affects the process of inflammatory disease including RA. Methods : In order to investigate the effect of Hominis Placenta extraction on MIF(early RA inducing cytokine) and MMP(Matrix Metallo Proteinase)-9 mRNA expression by means of Reverse Transcriptase- Polymerase Chain Reaction(RT-PCR). In this study, we investigated the effect of Hominis Placenta extraction on MIF(early RA inducing cytokine) and MMP-9 mRNA expression by means of RT-PCR. Besides we investigated changing of MIF in synovial membrane and, Interleukin-6 receptor(IL-6R)-