The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Uncooked Korean Food on Blood Glucose and Antioxidant Fnzyme Activities of Streptozotocin-induced Diabetic Rats

당뇨환자용 식사대용식이 Streptozotocin으로 유발된 당뇨쥐의 혈당 및 항산화 효소 활성에 미치는 영향

  • Bae, Han-Ho (Dawoom Oriental Medical Clinic, CharmDawoom Bio-Tec) ;
  • Song, See-Won (Dawoom Oriental Medical Clinic, CharmDawoom Bio-Tec) ;
  • Nam, Tae-Heung (Dawoom Oriental Medical Clinic, CharmDawoom Bio-Tec) ;
  • Cho, Chung-Sik (Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 배한호 (다움한의원, 참다움바이오텍) ;
  • 송시원 (다움한의원, 참다움바이오텍) ;
  • 남태흥 (다움한의원, 참다움바이오텍) ;
  • 조충식 (대전대학교 한의과대학 신계내과학교실)
  • Published : 2008.03.30
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Abstract

Objectives : This study has been carried out to understand the effect of Uncooked Korean Food(F-DM) on blood glucose and antioxidant enzyme activities in streptozotocin-induced Diabetic Rats. Methods : SD rats were separated into four groups(each with 20 rats). Except normal two group, the other two groups were injected into intra-peritoneal with streptozotocin 60 mg/kg. Experimental group was eated Feed with 25% F-DM for 4 weeks. The change of plasma glucose level, body weight were observed. After 4 weeks, liver and kidney weight, antioxidant enzyme activities, survival rate were observed with histological changes on liver, kidney and pancreas. Results : In experimental group, body weight and survival rate increased, plasma glucose level were decreased significantly. Liver and kidney weight, XOD activity were decreased in experimental group compared to control group. GSH-px and CAT activities, insulin- immunoreactive granules in p-cells were increased significantly in experimental group compared to control group. Conclusions : This study shows that the F-DM might be effective for treatment of diabetes and its complications, as well as reduction of the oxidative stress.

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