대한본초학회지 (The Korea Journal of Herbology)
- 제23권1호
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- Pages.23-28
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
소청용탕(小靑龍湯)이 천식(喘息)이 유발된 생쥐의 면역 글로불린 분비에 미치는 영향
Effects of Socheongryong-Tang on Immunoglobulin Production in Asthmatic Mice
- 정선 (동신대학교 한의과대학) ;
- 조수진 (고려대학교 의과대학) ;
- 문경일 (동신대학교 한의과대학) ;
- 김형우 (산업용가속기이용 생물연구센터) ;
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김부여
(경희대학교 치의학전문대학원) ;
- 조수인 (부산대학교 한의학전문대학원)
- Jung, Sun (College of Korean medicine, Dongshin University) ;
- Cho, Su-Jin (College of medicine, Korea University) ;
- Moon, Kyoung-Il (College of Korean medicine, Dongshin University) ;
- Kim, Hyung-Woo (Research Center of Industrial Accelerators) ;
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Kim, Bu-Yeo
(School of Dentistry, Kyung Hee University) ;
- Cho, Su-In (School of Oriental medicine, Pusan National University)
- 발행 : 2008.03.30
초록
Objectives : Socheongryong-Tang(小靑龍湯, SCRT), a herbal remedy, has been widely used to treat respiratory disease such as cough and asthma in Oriental countries. Recent years SCRT was known as anti-allergic agent. However, its therapeutic mechanisms including immunoglobuline such as IgE, IgG1, IgG2a productions are unclear. Methods : We investigated the effects of SCRT on levels of antigen specific total antibody, IgE, IgG1, IgG2a using ELISA method in serum from allergen-induced asthma mice. Results : SCRT decreased level of antigen specific IgE significantly. And SCRT treated mice showed downward tendency of IgG1, a Th1 relative antibody, level. But, SCRT did not affect levels of antigen specific total antibody and IgG2a, a Th1 relative antibody. Conclusions : we demonstrated the strong possibility of SCRT as a complementary or alternative drug to western drug also demonstrated that regulation of Th1/Th2 imbalance may be one of mechanism contributed to treatment for respiratory disease by SCRT.