대한본초학회지 (The Korea Journal of Herbology)

  • 제23권2호
  • /
  • Pages.81-85
  • /
  • 2008
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

마우스에서 황토국화 추출물의 급성독성 연구

Acute Toxicity Study on Mud chrysanthemum Indicum in Mice

  • 마진열 (한국한의학연구원) ;
  • 박화용 (한국한의학연구원) ;
  • 최한 (성균관대학교 약학대학 생약학실) ;
  • 지옥표 (성균관대학교 약학대학 생약학실) ;
  • 이재훈 (한국한의학연구원)
  • Ma, Jin-Yeul (Korea Institue of Oriental Medicine) ;
  • Park, Hwa-Yong (Korea Institue of Oriental Medicine) ;
  • Choi, Han (Pharmacognosy Lab, College of Pharmacy, SungKyunKwan University) ;
  • Zee, Ok-Pyo (Pharmacognosy Lab, College of Pharmacy, SungKyunKwan University) ;
  • Lee, Jae-Hoon (Korea Institue of Oriental Medicine)
  • 발행 : 2008.06.30
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초록

Objectives : The aim of this study is to collect data for toxicity and safety of Mud chrysanthemum indicum. Methods : In this study, we investigated the acute toxicity for buthanol-extracted Mud schrysanthemum indicum, 25 male and 25 female mice were observed for 14days after one day oral administration of Mud chrysanthemum indicum at the respective doses of 0(control group), 1024, 1280, 1600 and 2000mg/kg. Results : We observed survival rates, general toxicity, change of body weight and autopsy. No abnormality was found for all cases. Conclusions : The data confirmed that Mud chrysanthemum indicum is free from, the toxicity and safety problems. Compared with the control group, we could not find any toxic alteration in all treated groups (1024, 1280, 1600 and 2000mg/kg), In conclusion, LD50 of Mud chrysanthemum indicum was over 2000 mg/kg and it is very safe to mice.

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