The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Antimicrobial Effect on the Periodontal Pathogens and Anti-inflammatory Effect of Artemisiae Iwayomogii Herba

한인진(韓茵蔯)의 치주염세균에 대한 항균효과 및 항염효가

  • Kim, Young-Hong (Department of Meridian and Acupuncture, College of Eastern Medicine, Kyung Hee University) ;
  • Jeong, Mi-Young (WHO Collaborating Center for Traditional Medicine, East-West Medical Research Institute) ;
  • Lee, Na-Kyung (Department of Meridian and Acupuncture, College of Eastern Medicine, Kyung Hee University) ;
  • Lee, Jin-Yong (Department of Oral Microbiology, College of Dentistry, Kyung Hee University) ;
  • Herr, Yeek (Department of Periodontology, College of Dentistry, Kyung Hee University) ;
  • Lee, Je-Hyun (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Lim, Sabina (Department of Meridian and Acupuncture, College of Eastern Medicine, Kyung Hee University, WHO Collaborating Center for Traditional Medicine, East-West Medical Research Institute)
  • 김영홍 (경희대학교 한의과대학 경혈학교실) ;
  • 정미영 (경희대학교 WHO 전통의학연구협력센터 동서의학연구소) ;
  • 이나경 (경희대학교 한의과대학 경혈학교실) ;
  • 이진용 (경희대학교 치과대학 구강미생물학교실) ;
  • 허익 (경희대학교 치과대학 치주과학교실) ;
  • 이제현 (동국대학교 한의과대학 본초학교실) ;
  • 임사비나 (경희대학교 한의과대학 경혈학교실, 경희대학교 WHO 전통의학연구협력센터 동서의학연구소)
  • Published : 2008.06.30
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Abstract

Objectives : The purpose of this study was to evaluate on the antimicrobial effect on the periodontal pathogens and anti-inflammatory effect of Artemisiae Iwayomogii Herba. Artemisiae Iwayomogii Herba has been used for treating as Artemisiae Capilaris Herba in Korea. Methods : Artemisiae Iwayomogii Herba was prepared by extracting medicinal herb with water. We investigated antimicrobial activity by the minimun inhibitory concentration (MIC) test. We also investigated inhibition of IL-$1{\beta}$-induced collagenase-l(MMP-l), stromelysin-1(MMP-3), interleukin-6 gene expression in human gingival fibroblasts. Results : The antimicrobial effect of Artemisiae Iwayomogii Herba was evaluated with MIC against periodontopathogens; Porphyromonas gingivalis 2561, W50, A7A1-28, 9-14K-1, Prevotella intermedia28, and Actinobacillus actinomycetemcomitans Y4, MICs of Artemisiae Iwayomogii Herba were 0.156 mg/ml, 0.625 mg/ml, 0.313 mg/ml, 1.25 mg/ml, 10 mg/ml and 10 mg/ml. The anti-inflammatory effect of Artemisiae Iwayomogii Herba was evaluated with Influence of herbs on the IL-$1{\beta}$-induced expression of MMP-1, MMP-3, interleukin-6, IL-$1{\beta}$ increased MMP-1, MMP-3, interleukin-6 mRNA levels. Artemisiae Iwayomogii Herba significantly inhibited IL-$1{\beta}$-induced MMP-1, MMP-3, interleukin-6 gene expressions in a dose-dependent manner. Conclusions : These results suggested that Artemisiae Iwayomogii Herba might reduce the excessive proteolytic capacity of the gingival fibroblast during inflammation and could be developed a new drug in periodontitis.

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