Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of 12-week Aerobic Exercise Training on Cardiac Depolarization-repolarization Intervals and Cardiovascular Risk Profiles in Type 1 Diabetic Children

Type 1 당뇨 아동의 심장 탈분극 재분극 간격과 심혈관 위험인자에 대한 12주 유산소운동 트레이닝의 효과

  • Shin, Ki-Ok (Pusan National University Dept. of Physical Education) ;
  • Park, Chan-Ho (Pusan National University Dept. of Physical Education) ;
  • Park, Jung-Jun (Pusan National University Dept. of Physical Education)
  • 신기옥 (부산대학교 체육교육학과) ;
  • 박찬호 (부산대학교 체육교육학과) ;
  • 박정준 (부산대학교 체육교육학과)
  • Published : 2008.09.30
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Abstract

The purpose of this study was to investigate the effects of 12-week aerobic exercise training on cardiac QT intervals and cardiovascular risk profiles in type 1 diabetic children. Eleven type 1 diabetic children aged 9-17 years took part in this study as subject. The participants performed aerobic exercise training three times a week for total 12 weeks. The intensity of the training was adjusted at HRR 45% until three weeks and at HRR 55% since four weeks. After a 12-week aerobic exercise training systolic (p<0.05) and diastolic (p<0.05) blood pressure of the subjects was decreased. There was significant decrease in cardiac QT intervals (p<0.05), TC level (p<0.05), and HDL-C level (p<0.05). Therefore, the results of this study suggest that long-term regular physical activity of type 1 diabetic children considered exercise intensity and frequency may effect and play a important role in the prevention of diabetic complications and cardiovascular health care.

본 연구의 목적은 type 1 당뇨 아동에서 12주 유산소운동 트레이닝이 심장 QT 간격과 심혈관 위험 인자들에 어떠한 변화가 있는지를 조사하였다. 연구의 대상자는 9-17세 사이의 type 1 당뇨 아동 11명을 대상으로 하였다. 대상자들은 유산소운동 프로그램을 총 12주간 주 3회 실시하였다. 운동 강도는 3주까지 HRR 45%, 그 이후에는 HRR 55%를 적용하였다. 심장 QT 간격의 평가는 심박수 변이성 파워 스펙트랄 분석을 이용하였으며, 심혈관 위험인자들은 대상자들의 혈액 샘플을 채취하여 검사하였다. 연구결과 유산소운동 트레이닝 후 수축기 혈압(p<0.05)과 확장기 혈압(p<0.05)에서 유의한 감소가 있었다. 또한 심장 QT 간격(p<0.05), TC 농도(p<0.05), 그리고 HDL-C 농도(p<0.05)의 감소를 보였다. 이상의 연구결과와 선행연구를 고려할 때 운동 강도와 빈도가 고려된 장기간 규칙적인 신체활동은 type 1 당뇨 아동의 당뇨 합병증 예방 및 심혈관 건강관리에 효과적이고 중요한 작용을 할 수 있으리라 기대할 수 있다.

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References

  1. Algra, A., J. R. Tijssen, J. Pool and J. Lubsen. 1991. QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 83, 1888-1894. https://doi.org/10.1161/01.CIR.83.6.1888
  2. American College of Sports Medicine. 2001. ACSM's Resource Manual for Guidelines for Exercise Testing and Prescription, pp. 299-307, 4th eds., Lippincott WilIiams & Wilkins, Philadelphia.
  3. Baker, A 1986. Alteration in lipid and protein profile of plasma lipoprotein in middle aged men consequent to an aerobic exercise program. Metabolism 35, 1037-1043. https://doi.org/10.1016/0026-0495(86)90040-5
  4. Boudina, S. and E. D. Abel. 2005. Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes. Physiology 21, 250-258. https://doi.org/10.1152/physiol.00008.2006
  5. Bazett, H. C. n1920. An analysis of the time relation of electrocardiograms. Heart 7, 353-370.
  6. Bitar, A., J. Vernet, J. Coudert and M. Vermorel. 2000. Longitudinal changes in body composition, physical capacities and energy expenditure in boys and girls during the onset of puberty. Eur. J. Nutr. 39, 157-163. https://doi.org/10.1007/s003940070019
  7. Castaneda, C. 2003. Diabetes control with physical activity and exercise. Nutrition in clinical care: an official publication of Tufts University. Nut. Clin. Care 6, 89-96.
  8. De Bruyne, M. C., A. W. Hoes, J. A. Kors, A Hofman, J. H. Van Bemmel and D. E. Grobbee. 1999. Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study. Eur. Heart J. 20, 278-284. https://doi.org/10.1053/euhj.1998.1276
  9. Dekker, J. M., E. G. Schouten, P. Klootwijk, J. Pool and Kromhout, D. 1994. Association between QT interval and coronary heart disease in middle-aged and elderly men.: The Zutphen study. Circulation 90, 779-785. https://doi.org/10.1161/01.CIR.90.2.779
  10. Dixon, E. M., M. V. Kamath, N. McCartney and E. L. Fallen. 1992. Neural regulation of heart rate variability in endurance athletes and sedentary controls. Cardiovasc Res. 26, 713-719. https://doi.org/10.1093/cvr/26.7.713
  11. Ertl, A and S. N. Davis. 2004. Evidence for a vicious cycle of exercise and hypoglycaemia in type 1 diabetes mellitus. Diabetes Metabolism Res Rev. 20, 124-130. https://doi.org/10.1002/dmrr.450
  12. Festa, A, R. J. R. D'Agostino, P. Rautaharju, D. H. O'Leary, M. Rewers, L. Mykkanen and S. M. Haffner. 1999. Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects?: The insulin resistance ahterosclerosis study (IRAS). Stroke 30, 1566-1571. https://doi.org/10.1161/01.STR.30.8.1566
  13. Genovesi, S., D. Zaccaria, E. Rossi, M. G. Valsecchi, A, Stella and M. Stramba-Badiale. 2007. Effects of exercise training on heart rate and QT interval in healthy young individuals: Are there gender differenecs? Europace 9, 55-60.
  14. Hoffman, J. 2002. Physiological aspects of sport training and performance. In: Human Kinetics, pp. 274-283.
  15. Harumi, K., G. R. Smith, J. A. Abildskov, M. J. Burgess, R. L. Lux and R. F. Wyatt. 1980. Detailed activation sequence in the region of electrically induced ventricular fibrillation in dogs. Jpn. Heart J. 21, 533-544. https://doi.org/10.1536/ihj.21.533
  16. Hayashi, H., R. L. Lux, R. F. Wyatt, M. J. Burgess and J. A. Abildskov. 1982. Relation of canine atrial activation sequence to anatomic landmarks. Am. J. Physiol. 242, H421-H428.
  17. Herbst, A., O. Kordonouri, K. O. Schwab, F. Schmidt, R. W. Holl and DPV initiative of the German working group for pediatric diabetology Germany. 2007. Impact of physical activity on cardiovascular risk factors in children with type 1 diabetes. Diabetes Care 30, 2098-2100. https://doi.org/10.2337/dc06-2636
  18. Hull, S. S., E. Vanoli, P. B. Adamson, R. L. Verrier, R. D. Foreman and P. J. Schwartz. 1994. Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation 89, 548-552. https://doi.org/10.1161/01.CIR.89.2.548
  19. Lehmann, R., V. Kaplan, R. Bingisser, K. E. Bloch and G. A. Spinas. 1997. Impact of physical activity on cardiovascular risk factors in IDDM. Diabetes Care 20, 1603-1611. https://doi.org/10.2337/diacare.20.10.1603
  20. Lowes, L. and J. W. Gregory. 2004. Management of newly diagnosed diabetes: hone or hospital? Arch. Dis. Childhood 89, 934-937. https://doi.org/10.1136/adc.2003.035949
  21. Moritani, T., T. Kimura, T. Hamada and N. Nagai. 2005. Electrophysiology and kinesiology for health and disease. J. Electromyogr. Kinesiol. 15, 240-255. https://doi.org/10.1016/j.jelekin.2005.01.001
  22. Moss, A. J. 1995. Long QT syndrome, pp. 1110-1120, Tn Podrid, P. J. and P. R Kowey (eds.), Cardiac arrhythmia, Williams & Wilkins Ltd., Boltimore.
  23. Rossing, P., L. Breum, A. Major-Pedersen, A. Sato, H. Winding, A. Pietersen, J. Kastrup and H. H. Parving. 2001. Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus. Diabet. Med. 18, 199-205. https://doi.org/10.1046/j.1464-5491.2001.00446.x
  24. Salles, G. F., W. Deccache and C. R. Cardoso. 2005. Usefulness of QT interval parameters for cardiovascular risk stratification in type 2 diabetic patients with arterial hypertension. J. Hum. Hypertens. 19, 241-249.
  25. Schouten, E. G., J. M. Dekker, P. Meppelink, F. J. Kok, J. P. Vandenbroucke and J. Pool. 1991. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 84, 1516-1523. https://doi.org/10.1161/01.CIR.84.4.1516
  26. Schuit, A. J., J. M. Dekker, F. de Vegt, T. C. Verheij, R. D. Rijneke and E. G. Schouten. 1998. Effect of physical training on QTc interval in elderly people. J. Electrocardiol. 31, 111-116. https://doi.org/10.1016/S0022-0736(98)90041-3
  27. Schwab, K. O., J. Doerfer, W. Hecker, J. Grulich-Henn, D. Wiemann, O. Kordonouri, P. Beyer and R. W. Holl. 2006. Spectrum and prevalence of atherogenic risk factors in 27,358 children, adolescents, and young adults with type 1 diabetes: cross-sectional data from the German diabetes documentation and quality management system DPV. Diabetes Care 29, 218-225. https://doi.org/10.2337/diacare.29.02.06.dc05-0724
  28. Schwartz, P. J., M. Stramba-Badiale, A. Segantini, P. Austoni, G. Bosi, R. Giorgetti, F. Grancini, E. D. Mami, F. Perticone, D. Rosti and P. Salice. 1998. Prolongation of the QT interval and the sudden infant death syndrome. N. Engl. J. Med. 338, 1709-1714. https://doi.org/10.1056/NEJM199806113382401
  29. Silverstein, J., G. Klingensmith, K. Copeland, L. Plotnick, F. Kaufman, L. Laffel, L. Deeb, M. Grev, B. Anderson, L. A. Holzmeister, N. Clark and American Diabetes Association. 2005. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care 28, 186-212. https://doi.org/10.2337/diacare.28.1.186
  30. Stettler, C. A. Bearth, S. Allemann, M. Zwahlen, L. Zanchin, M. Deplazes, E. R. Christ, A. Teuscher and P. Diem. 2007. QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up. Diabetologia 50, 186-194. https://doi.org/10.1007/s00125-006-0483-1
  31. Suys, B. E., S. J. Huybrechts, D. De Wolf, L. Op De Beeck, D. Matthys, B. Van Overmeire, M. V. Du Caju and R. P. Rooman, 2002. QTc interval prolongation and QTc dispersion in children and adolescents with type 1 diabetes. J. Pediater. 141, 59-63. https://doi.org/10.1067/mpd.2002.125175
  32. The diabetes control and complications trial research group. 1993. The effect of internsive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977-986. https://doi.org/10.1056/NEJM199309303291401
  33. Ue, H., I. Masuda, Y. Yoshitake and T. Moritani, 2000. Assessment of caridac autonomic nervous activities by means of ECG R-R interval power spectral analysis and cardiac depoloarization-repolarization process. A. N. E. 5, 336-345.
  34. Zimmet, P., K. G. Alberti and J. Shaw. 2001. global and societal implications of the diabetes epidemic. Nature 414, 782-787. https://doi.org/10.1038/414782a
  35. Zoppini, G., M. Carlini and M. Muggeo. 2003. Self-reported exercise and quality of life in young type 1 diabetic subjects. Diabetes Nutr. Metab. 16, 77-80.